FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042301222> ?p ?o ?g. }

• W2042301222 abstract "Semantic similarity measures are useful to assess the physiological relevance of protein-protein interactions (PPIs). They quantify similarity between proteins based on their function using annotation systems like the Gene Ontology (GO). Proteins that interact in the cell are likely to be in similar locations or involved in similar biological processes compared to proteins that do not interact. Thus the more semantically similar the gene function annotations are among the interacting proteins, more likely the interaction is physiologically relevant. However, most semantic similarity measures used for PPI confidence assessment do not consider the unequal depth of term hierarchies in different classes of cellular location, molecular function, and biological process ontologies of GO and thus may over-or under-estimate similarity. We describe an improved algorithm, Topological Clustering Semantic Similarity (TCSS), to compute semantic similarity between GO terms annotated to proteins in interaction datasets. Our algorithm, considers unequal depth of biological knowledge representation in different branches of the GO graph. The central idea is to divide the GO graph into sub-graphs and score PPIs higher if participating proteins belong to the same sub-graph as compared to if they belong to different sub-graphs. The TCSS algorithm performs better than other semantic similarity measurement techniques that we evaluated in terms of their performance on distinguishing true from false protein interactions, and correlation with gene expression and protein families. We show an average improvement of 4.6 times the F1 score over Resnik, the next best method, on our Saccharomyces cerevisiae PPI dataset and 2 times on our Homo sapiens PPI dataset using cellular component, biological process and molecular function GO annotations." @default.
• W2042301222 created "2016-06-24" @default.
• W2042301222 creator A5010789029 @default.
• W2042301222 creator A5054711725 @default.
• W2042301222 date "2010-11-15" @default.
• W2042301222 modified "2023-10-09" @default.
• W2042301222 title "An improved method for scoring protein-protein interactions using semantic similarity within the gene ontology" @default.
• W2042301222 cites W1517294127 @default.
• W2042301222 cites W1533335653 @default.
• W2042301222 cites W1811927564 @default.
• W2042301222 cites W1918391659 @default.
• W2042301222 cites W1958717431 @default.
• W2042301222 cites W1980948656 @default.
• W2042301222 cites W1985213868 @default.
• W2042301222 cites W1995407213 @default.
• W2042301222 cites W1995842607 @default.
• W2042301222 cites W2017936606 @default.
• W2042301222 cites W2020556380 @default.
• W2042301222 cites W2046482984 @default.
• W2042301222 cites W2050721857 @default.
• W2042301222 cites W2055867223 @default.
• W2042301222 cites W2065304353 @default.
• W2042301222 cites W2084168100 @default.
• W2042301222 cites W2085032889 @default.
• W2042301222 cites W2097624459 @default.
• W2042301222 cites W2100761975 @default.
• W2042301222 cites W2101181377 @default.
• W2042301222 cites W2102037268 @default.
• W2042301222 cites W2103017472 @default.
• W2042301222 cites W2109248504 @default.
• W2042301222 cites W2116117181 @default.
• W2042301222 cites W2117513900 @default.
• W2042301222 cites W2121343862 @default.
• W2042301222 cites W2121822754 @default.
• W2042301222 cites W2126225210 @default.
• W2042301222 cites W2127536416 @default.
• W2042301222 cites W2128049108 @default.
• W2042301222 cites W2132290594 @default.
• W2042301222 cites W2134789671 @default.
• W2042301222 cites W2144541737 @default.
• W2042301222 cites W2153577994 @default.
• W2042301222 cites W2155320925 @default.
• W2042301222 cites W2157422578 @default.
• W2042301222 cites W2161759592 @default.
• W2042301222 cites W2163485494 @default.
• W2042301222 cites W2164105194 @default.
• W2042301222 cites W2169896388 @default.
• W2042301222 cites W2172049947 @default.
• W2042301222 cites W2173931094 @default.
• W2042301222 cites W4211208250 @default.
• W2042301222 cites W4234895322 @default.
• W2042301222 doi "https://doi.org/10.1186/1471-2105-11-562" @default.
• W2042301222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2998529" @default.
• W2042301222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21078182" @default.
• W2042301222 hasPublicationYear "2010" @default.
• W2042301222 type Work @default.
• W2042301222 sameAs 2042301222 @default.
• W2042301222 citedByCount "156" @default.
• W2042301222 countsByYear W20423012222012 @default.
• W2042301222 countsByYear W20423012222013 @default.
• W2042301222 countsByYear W20423012222014 @default.
• W2042301222 countsByYear W20423012222015 @default.
• W2042301222 countsByYear W20423012222016 @default.
• W2042301222 countsByYear W20423012222017 @default.
• W2042301222 countsByYear W20423012222018 @default.
• W2042301222 countsByYear W20423012222019 @default.
• W2042301222 countsByYear W20423012222020 @default.
• W2042301222 countsByYear W20423012222021 @default.
• W2042301222 countsByYear W20423012222022 @default.
• W2042301222 countsByYear W20423012222023 @default.
• W2042301222 crossrefType "journal-article" @default.
• W2042301222 hasAuthorship W2042301222A5010789029 @default.
• W2042301222 hasAuthorship W2042301222A5054711725 @default.
• W2042301222 hasBestOaLocation W20423012221 @default.
• W2042301222 hasConcept C103278499 @default.
• W2042301222 hasConcept C104317684 @default.
• W2042301222 hasConcept C111472728 @default.
• W2042301222 hasConcept C115961682 @default.
• W2042301222 hasConcept C124101348 @default.
• W2042301222 hasConcept C130318100 @default.
• W2042301222 hasConcept C132525143 @default.
• W2042301222 hasConcept C138885662 @default.
• W2042301222 hasConcept C141231307 @default.
• W2042301222 hasConcept C150194340 @default.
• W2042301222 hasConcept C154945302 @default.
• W2042301222 hasConcept C17744445 @default.
• W2042301222 hasConcept C199539241 @default.
• W2042301222 hasConcept C207060522 @default.
• W2042301222 hasConcept C23123220 @default.
• W2042301222 hasConcept C25810664 @default.
• W2042301222 hasConcept C2776359362 @default.
• W2042301222 hasConcept C2908923196 @default.
• W2042301222 hasConcept C2986374874 @default.
• W2042301222 hasConcept C2987395477 @default.
• W2042301222 hasConcept C41008148 @default.
• W2042301222 hasConcept C54355233 @default.
• W2042301222 hasConcept C70721500 @default.
• W2042301222 hasConcept C73555534 @default.
• W2042301222 hasConcept C80444323 @default.
• W2042301222 hasConcept C86803240 @default.

• next