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• W2042303206 endingPage "1197" @default.
• W2042303206 startingPage "1185" @default.
• W2042303206 abstract "The TonB protein transduces energy from the proton gradient across the cytoplasmic membrane of Gram-negative bacteria to TonB-dependent outer membrane receptors. It is a critically important protein in iron uptake, and deletion of this protein is known to decrease virulence of bacteria in animal models. This system has been used for Trojan horse antibiotic delivery. Here, we describe the high-resolution solution structure of Escherichia coli TonB residues 103–239 (TonB-CTD). TonB-CTD is monomeric with an unstructured N terminus (103–151) and a well structured C terminus (152–239). The structure contains a four-stranded antiparallel β-sheet packed against two α-helices and an extended strand in a configuration homologous to the C-terminal domain of the TolA protein. Chemical shift perturbations to the TonB-CTD 1H-15N HSCQ spectrum titrated with TonB box peptides modeled from the E. coli FhuA, FepA and BtuB proteins were all equivalent, indicating that all three peptides bind to the same region of TonB. Isothermal titration calorimetry measurements demonstrate that TonB-CTD interacts with the FhuA-derived peptide with a KD=36(±7) μM. On the basis of chemical shift data, the position of Gln160, and comparison to the TolA gp3 N1 complex crystal structure, we propose that the TonB box binds to TonB-CTD along the β3-strand." @default.
• W2042303206 created "2016-06-24" @default.
• W2042303206 creator A5020743689 @default.
• W2042303206 creator A5026935265 @default.
• W2042303206 creator A5027651656 @default.
• W2042303206 creator A5042190192 @default.
• W2042303206 creator A5086558946 @default.
• W2042303206 date "2005-02-01" @default.
• W2042303206 modified "2023-10-16" @default.
• W2042303206 title "The Solution Structure of the C-terminal Domain of TonB and Interaction Studies with TonB Box Peptides" @default.
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• W2042303206 doi "https://doi.org/10.1016/j.jmb.2004.11.026" @default.
• W2042303206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15644214" @default.
• W2042303206 hasPublicationYear "2005" @default.
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• W2042303206 hasAuthorship W2042303206A5027651656 @default.
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