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- W2042306434 abstract "Background and Objective: The Epithelial-to-Mesenchymal Transition (EMT) is a developmental program which is often reactivated in aggressive metastatic breast cancer. Several transcription factors (TFs), such as Snail and ZEB can act as master regulators of EMT, directly repressing the gene for E-cadherin. We sought to identify common gene expression signatures characteristic to both EMT and a reverse process, Mesenchymal-to-Epithelial Transition (MET). Methods: Using Affymetrix Exon microarrays we characterized global gene expression changes in two cellular models: normal mammary epithelial HMLE cells induced to undergo EMT by expression of Snail1, Snail2 or ZEB1; and MDA-MB-231LN breast cancer cells induced to undergo MET by depletion of ZEB1 and ZEB2. Results: We identified two large gene sets: 1) 1017 genes down-regulated during EMT and up-regulated during MET, which we designated as MET-specific; and 2) 438 genes up-regulated during EMT and down-regulated during MET, which we designated as EMT-specific. 14 TFs were found in the EMT category. Their functional validation showed that individual overexpression of several of these TFs in HMLE cells was sufficient to elicit partial EMT. Discussion and Conclusions: Our comprehensive analysis of gene expression signatures common to EMT and MET identifies the EMT transcriptional program characteristic to invasive metastatic breast cancer. Grant support: NIH NCRR grant P20 RR16440 and Susan G. Komen for the Cure grant KG110350. Citation Format: Maria Voronkova, Joseph Addison, Renata Galeeva, James Denvir, Dongquan Chen, Alexey Ivanov. Gene expression profiling during EMT and MET identifies multiple transcription factors involved in the EMT transcriptional reprogramming. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr B94." @default.
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- W2042306434 date "2013-02-01" @default.
- W2042306434 modified "2023-09-27" @default.
- W2042306434 title "Abstract B94: Gene expression profiling during EMT and MET identifies multiple transcription factors involved in the EMT transcriptional reprogramming" @default.
- W2042306434 doi "https://doi.org/10.1158/1538-7445.tim2013-b94" @default.
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