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- W204230791 abstract "To establish a psychological stress model, we characterized in rats the effects of chronic (5-6 wk) scheduled food pellet feeding (35 mg/80 s for 8 h/day). Because the scheduled intake of pellets required that rats have access to 80% of ad libitum intake, the effect of food restriction was also examined by withholding food intermittently for 24 or 48 h each, followed by 24 h free access to food. Cardiac norepinephrine concentration was significantly increased (1,076 +/- 169 vs. 693 +/- 107 ng/g, P < 0.05) in rats subjected to pellet feeding compared with pair-fed rats (same amount of pellets in one portion) or 24- or 48-h intermittently fasted rats; similarly, the epinephrine content of adrenal glands was increased (P < 0.05). Left ventricular rate of sarcoplasmic reticulum Ca2+ uptake was decreased (P < 0.05) compared with pair-fed rats, reaching values observed for 24-h fasted rats, whereas the proportion of alpha-myosin heavy chains was only slightly reduced. Thus the schedule-induced stress arising from pellet feeding exhibits features of stress models involving physical pain and appears to stimulate the adrenergic system with subsequent impairment of Ca2+ cycling that is typical of various heart diseases." @default.
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- W204230791 date "1997-03-01" @default.
- W204230791 modified "2023-10-16" @default.
- W204230791 title "Schedule-induced psychological stress and molecular structures of cardiomyocytes" @default.
- W204230791 doi "https://doi.org/10.1152/ajpregu.1997.272.3.r776" @default.
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