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• W2042314109 abstract "The resistance of the corneal stroma to the flow of water has been studied both along and across the tissue as well as at various degrees of hydration. In the investigations of flow along the stroma a marked difference in thickness was generated by allowing a part of the corneal strip to swell and the adjacent part to dry. Water equilibrium along the strip was established by the water movement from the swollen to the dry part and the profile was evened out. By repeated measurements of thickness along the strip, it was possible to estimate the flow of water. Since the relationship between thickness and swelling pressure was known, the pressure gradient along the cornea could be determined. For these determinations a new instrument was designed and is described in detail. The results showed a flow of water of approximately 0.6 × 10−3 mm/hr for a pressure gradient of 1 mm Hg/mm. The flow of water across the corneal stroma was determined by pressing 0.9% NaCl or water through the tissue while tightly sealed in a holder between two porous stainless-steel filters and collecting the water in a capillary. The resistance to flow in the two directions was found to be similar at normal hydration, but for dried cornea the resistance was higher across the tissue than along it. Since calculations show that the collagen fibrils alone offer only 1/50 of the measured resistance, it is suggested that the interfibrillar substance is responsible for the high resistance to the flow of water in the corneal stroma." @default.
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• W2042314109 date "1962-03-01" @default.
• W2042314109 modified "2023-10-18" @default.
• W2042314109 title "Flow of water in the corneal stroma" @default.
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• W2042314109 doi "https://doi.org/10.1016/s0014-4835(62)80010-4" @default.
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