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- W2042318249 abstract "To determine the effects of inhaled 144Ce, 126 Beagle dogs (including 15 controls) were exposed to aerosols of either 144Ce in fused clay or stable cerium in fused clay. To date, 15 dogs have died 143–410 days after inhalation exposure from radiation pneumonitis and pulmonary fibrosis. Primary pulmonary neoplasms caused the deaths of 5 dogs 750–1318 days after inhalation exposure. Calculated pulmonary radiation doses until death ranged from 23,000–48,000 rads. Pulmonary hemangiosarcomas were found in all 5 dogs and metastasis in 4. In addition, 1 dog had a pulmonary fibrosarcoma and another had a bronchiolo-alveolar carcinoma, both of which metastasized to the tracheobronchial lymph nodes. Only 3 dogs with similar initial lung burdens of 144Ce died without pulmonary neoplasms, at 186, 193, and 410 days after inhalation exposure. The 91 dogs exposed to 144Ce-fused clay and all controls have survived 239–1565 days after inhalation exposure including 44 surviving >750 days, with pulmonary radiation doses from 2–36,000 rads." @default.
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- W2042318249 date "1973-03-01" @default.
- W2042318249 modified "2023-09-26" @default.
- W2042318249 title "Primary Pulmonary Neoplasms in Beagle Dogs Exposed to Aerosols of 144Ce in Fused-Clay Particless2" @default.
- W2042318249 doi "https://doi.org/10.1093/jnci/50.3.675" @default.
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