Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042323754> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2042323754 abstract "The biliary excretion of grepafloxacin (GPFX) was compared with that of lomefloxacin (LFLX) in rats. The biliary clearances (Cl(plasma)(bile)) of GPFX was 2.9 times greater than LFLX based on the plasma concentration reached during constant intravenous (i.v.) infusion. The liver-plasma unbound concentration ratio, K(pu), of GPFX (1.7) was also higher than that of LFLX (0.7). The hepatic uptake clearance, assessed from an integration plot analysis, of GPFX was comparable with the hepatic blood flow rate, and 1.5 times that of LFLX, indicating that membrane transport in the uptake process is more efficient for GPFX. This was also supported by the difference between the uptake clearance of GPFX and LFLX in isolated rat hepatocytes. The bile-liver unbound concentration ratio of GPFX and LFLX was approximately 6 and 3, respectively, and the biliary clearance based on the unbound liver concentration of GPFX was 1.8 times that of LFLX. These results suggest that the concentrative transport of GPFX also across the canalicular membrane was more efficient than that of LFLX. Thus, the membrane transport activity via both sinusoidal and canalicular membranes determines the net excretion of each compound." @default.
- W2042323754 created "2016-06-24" @default.
- W2042323754 creator A5027984186 @default.
- W2042323754 creator A5051094265 @default.
- W2042323754 creator A5052348746 @default.
- W2042323754 creator A5082252519 @default.
- W2042323754 creator A5086918055 @default.
- W2042323754 date "1999-04-01" @default.
- W2042323754 modified "2023-10-03" @default.
- W2042323754 title "Differences in the hepatobiliary transport of two quinolone antibiotics, grepafloxacin and lomefloxacin, in the rat" @default.
- W2042323754 cites W102035533 @default.
- W2042323754 cites W140076755 @default.
- W2042323754 cites W1502459074 @default.
- W2042323754 cites W1540993333 @default.
- W2042323754 cites W1551662159 @default.
- W2042323754 cites W1557322059 @default.
- W2042323754 cites W1646404713 @default.
- W2042323754 cites W1968763311 @default.
- W2042323754 cites W1970766250 @default.
- W2042323754 cites W2065038872 @default.
- W2042323754 cites W2101089117 @default.
- W2042323754 cites W2314285093 @default.
- W2042323754 cites W2414458541 @default.
- W2042323754 cites W2887116887 @default.
- W2042323754 cites W4293247451 @default.
- W2042323754 doi "https://doi.org/10.1002/(sici)1099-081x(199904)20:3<151::aid-bdd168>3.0.co;2-p" @default.
- W2042323754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10211868" @default.
- W2042323754 hasPublicationYear "1999" @default.
- W2042323754 type Work @default.
- W2042323754 sameAs 2042323754 @default.
- W2042323754 citedByCount "17" @default.
- W2042323754 countsByYear W20423237542013 @default.
- W2042323754 countsByYear W20423237542014 @default.
- W2042323754 crossrefType "journal-article" @default.
- W2042323754 hasAuthorship W2042323754A5027984186 @default.
- W2042323754 hasAuthorship W2042323754A5051094265 @default.
- W2042323754 hasAuthorship W2042323754A5052348746 @default.
- W2042323754 hasAuthorship W2042323754A5082252519 @default.
- W2042323754 hasAuthorship W2042323754A5086918055 @default.
- W2042323754 hasConcept C10146269 @default.
- W2042323754 hasConcept C112705442 @default.
- W2042323754 hasConcept C126322002 @default.
- W2042323754 hasConcept C134018914 @default.
- W2042323754 hasConcept C185592680 @default.
- W2042323754 hasConcept C2778049240 @default.
- W2042323754 hasConcept C2778512257 @default.
- W2042323754 hasConcept C2778923102 @default.
- W2042323754 hasConcept C3019249092 @default.
- W2042323754 hasConcept C3020079912 @default.
- W2042323754 hasConcept C41625074 @default.
- W2042323754 hasConcept C43617362 @default.
- W2042323754 hasConcept C501593827 @default.
- W2042323754 hasConcept C55493867 @default.
- W2042323754 hasConcept C71924100 @default.
- W2042323754 hasConcept C98274493 @default.
- W2042323754 hasConceptScore W2042323754C10146269 @default.
- W2042323754 hasConceptScore W2042323754C112705442 @default.
- W2042323754 hasConceptScore W2042323754C126322002 @default.
- W2042323754 hasConceptScore W2042323754C134018914 @default.
- W2042323754 hasConceptScore W2042323754C185592680 @default.
- W2042323754 hasConceptScore W2042323754C2778049240 @default.
- W2042323754 hasConceptScore W2042323754C2778512257 @default.
- W2042323754 hasConceptScore W2042323754C2778923102 @default.
- W2042323754 hasConceptScore W2042323754C3019249092 @default.
- W2042323754 hasConceptScore W2042323754C3020079912 @default.
- W2042323754 hasConceptScore W2042323754C41625074 @default.
- W2042323754 hasConceptScore W2042323754C43617362 @default.
- W2042323754 hasConceptScore W2042323754C501593827 @default.
- W2042323754 hasConceptScore W2042323754C55493867 @default.
- W2042323754 hasConceptScore W2042323754C71924100 @default.
- W2042323754 hasConceptScore W2042323754C98274493 @default.
- W2042323754 hasLocation W20423237541 @default.
- W2042323754 hasLocation W20423237542 @default.
- W2042323754 hasOpenAccess W2042323754 @default.
- W2042323754 hasPrimaryLocation W20423237541 @default.
- W2042323754 hasRelatedWork W1966094145 @default.
- W2042323754 hasRelatedWork W1968971582 @default.
- W2042323754 hasRelatedWork W2021846613 @default.
- W2042323754 hasRelatedWork W2022389305 @default.
- W2042323754 hasRelatedWork W2034296097 @default.
- W2042323754 hasRelatedWork W2050178395 @default.
- W2042323754 hasRelatedWork W2059373368 @default.
- W2042323754 hasRelatedWork W2093166709 @default.
- W2042323754 hasRelatedWork W2104218156 @default.
- W2042323754 hasRelatedWork W2117611353 @default.
- W2042323754 isParatext "false" @default.
- W2042323754 isRetracted "false" @default.
- W2042323754 magId "2042323754" @default.
- W2042323754 workType "article" @default.