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• W2042332016 abstract "We examined activation of the mTOR signaling pathway in situ in the primary, normal reactive and patient-derived post-transplant lymphoproliferative disorder (PTLD) tissue samples. We accomplished this analysis by immunohistochemistry on formalin-fixed, paraffin-embedded specimens using a set of highly specific antibodies that permitted us to determine phosphorylation status of the key serines in the mTOR target proteins. Our results demonstrate that the mTOR signaling pathway is activated in reactive tissue in a highly distinct fashion with positive, typically enlarged cells being present primarily in the germinal center and, to a lesser degree, in interfollicular areas with mantle zone being conspicuously negative. We could demonstrate mTOR activation in the lesional cells in the entire spectrum of PTLD subtypes, regardless of their Epstein–Barr virus genome expression status. These data demonstrate the ubiquitous activation of the mTOR signaling pathway in PTLD and indicate that mTOR inhibitors may be effective in treatment and, notably, prevention of PTLDs given their immunosuppressive properties. Furthermore, our results define potential biomarkers of the therapeutic response. Because the constitutive mTOR activation has also been identified in cells isolated from other hematologic malignancies, the ability to examine the in vivo mTOR signaling may have implications reaching beyond the PTLD field." @default.
• W2042332016 created "2016-06-24" @default.
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• W2042332016 date "2007-01-01" @default.
• W2042332016 modified "2023-10-18" @default.
• W2042332016 title "Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders" @default.
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• W2042332016 doi "https://doi.org/10.1038/labinvest.3700494" @default.
• W2042332016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17075574" @default.
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