Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042334010> ?p ?o ?g. }
- W2042334010 endingPage "1153" @default.
- W2042334010 startingPage "1147" @default.
- W2042334010 abstract "Maternal smoking during pregnancy is associated with significant infant morbidity and mortality, and may influence later disease risk. One mechanism by which smoking (and other environmental factors) might have long-lasting effects is through epigenetic modifications such as DNA methylation.We conducted an epigenome-wide association study (EWAS) investigating alterations in DNA methylation in infants exposed in utero to maternal tobacco smoke, using the Norway Facial Clefts Study.The Illumina HumanMethylation450 BeadChip was used to assess DNA methylation in whole blood from 889 infants shortly after delivery. Of 889 mothers, 287 reported smoking-twice as many smokers as in any previous EWAS of maternal smoking. CpG sites related to maternal smoking during the first trimester were identified using robust linear regression.We identified 185 CpGs with altered methylation in infants of smokers at genome-wide significance (q-value < 0.05; mean Δβ = ± 2%). These correspond to 110 gene regions, of which 7 have been previously reported and 10 are newly confirmed using publicly available results. Among these 10, the most noteworthy are FRMD4A, ATP9A, GALNT2, and MEG3, implicated in processes related to nicotine dependence, smoking cessation, and placental and embryonic development.Our study identified 10 genes with newly established links to maternal smoking. Further, we note differences between smoking-related methylation changes in newborns and adults, suggesting possible distinct effects of direct versus indirect tobacco smoke exposure as well as potential differences due to age. Further work would be needed to determine whether these small changes in DNA methylation are biologically or clinically relevant. The methylation changes identified in newborns may mediate the association between in utero maternal smoking exposure and later health outcomes." @default.
- W2042334010 created "2016-06-24" @default.
- W2042334010 creator A5024312010 @default.
- W2042334010 creator A5036890213 @default.
- W2042334010 creator A5047670086 @default.
- W2042334010 creator A5066839852 @default.
- W2042334010 creator A5075573311 @default.
- W2042334010 creator A5080454757 @default.
- W2042334010 creator A5089462484 @default.
- W2042334010 date "2014-10-01" @default.
- W2042334010 modified "2023-10-05" @default.
- W2042334010 title "Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during Pregnancy" @default.
- W2042334010 cites W1530388847 @default.
- W2042334010 cites W1964895626 @default.
- W2042334010 cites W1968192565 @default.
- W2042334010 cites W1975466038 @default.
- W2042334010 cites W1989126702 @default.
- W2042334010 cites W1989414037 @default.
- W2042334010 cites W2002798737 @default.
- W2042334010 cites W2004078197 @default.
- W2042334010 cites W2006345816 @default.
- W2042334010 cites W2011988545 @default.
- W2042334010 cites W2019664163 @default.
- W2042334010 cites W2022484411 @default.
- W2042334010 cites W2023401861 @default.
- W2042334010 cites W2023907384 @default.
- W2042334010 cites W2029033394 @default.
- W2042334010 cites W2030111741 @default.
- W2042334010 cites W2036691685 @default.
- W2042334010 cites W2042335606 @default.
- W2042334010 cites W2044342281 @default.
- W2042334010 cites W2044481346 @default.
- W2042334010 cites W2047837749 @default.
- W2042334010 cites W2050727153 @default.
- W2042334010 cites W2066480642 @default.
- W2042334010 cites W2067546738 @default.
- W2042334010 cites W2070490017 @default.
- W2042334010 cites W2077723521 @default.
- W2042334010 cites W2084601112 @default.
- W2042334010 cites W2089431747 @default.
- W2042334010 cites W2092119400 @default.
- W2042334010 cites W2094889529 @default.
- W2042334010 cites W2101526557 @default.
- W2042334010 cites W2103421101 @default.
- W2042334010 cites W2109099198 @default.
- W2042334010 cites W2115801316 @default.
- W2042334010 cites W2125180026 @default.
- W2042334010 cites W2140288082 @default.
- W2042334010 cites W2144998962 @default.
- W2042334010 cites W2147032768 @default.
- W2042334010 cites W2148062286 @default.
- W2042334010 cites W2148449057 @default.
- W2042334010 cites W2158946829 @default.
- W2042334010 cites W2160323702 @default.
- W2042334010 cites W2169556367 @default.
- W2042334010 doi "https://doi.org/10.1289/ehp.1307892" @default.
- W2042334010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4181928" @default.
- W2042334010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24906187" @default.
- W2042334010 hasPublicationYear "2014" @default.
- W2042334010 type Work @default.
- W2042334010 sameAs 2042334010 @default.
- W2042334010 citedByCount "164" @default.
- W2042334010 countsByYear W20423340102014 @default.
- W2042334010 countsByYear W20423340102015 @default.
- W2042334010 countsByYear W20423340102016 @default.
- W2042334010 countsByYear W20423340102017 @default.
- W2042334010 countsByYear W20423340102018 @default.
- W2042334010 countsByYear W20423340102019 @default.
- W2042334010 countsByYear W20423340102020 @default.
- W2042334010 countsByYear W20423340102021 @default.
- W2042334010 countsByYear W20423340102022 @default.
- W2042334010 countsByYear W20423340102023 @default.
- W2042334010 crossrefType "journal-article" @default.
- W2042334010 hasAuthorship W2042334010A5024312010 @default.
- W2042334010 hasAuthorship W2042334010A5036890213 @default.
- W2042334010 hasAuthorship W2042334010A5047670086 @default.
- W2042334010 hasAuthorship W2042334010A5066839852 @default.
- W2042334010 hasAuthorship W2042334010A5075573311 @default.
- W2042334010 hasAuthorship W2042334010A5080454757 @default.
- W2042334010 hasAuthorship W2042334010A5089462484 @default.
- W2042334010 hasBestOaLocation W20423340101 @default.
- W2042334010 hasConcept C104317684 @default.
- W2042334010 hasConcept C117717151 @default.
- W2042334010 hasConcept C126322002 @default.
- W2042334010 hasConcept C140173407 @default.
- W2042334010 hasConcept C150194340 @default.
- W2042334010 hasConcept C190727270 @default.
- W2042334010 hasConcept C2776319443 @default.
- W2042334010 hasConcept C2778355491 @default.
- W2042334010 hasConcept C2779234561 @default.
- W2042334010 hasConcept C2779547902 @default.
- W2042334010 hasConcept C33288867 @default.
- W2042334010 hasConcept C41091548 @default.
- W2042334010 hasConcept C42407357 @default.
- W2042334010 hasConcept C54355233 @default.
- W2042334010 hasConcept C60644358 @default.
- W2042334010 hasConcept C71924100 @default.
- W2042334010 hasConcept C86803240 @default.