FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042334626> ?p ?o ?g. }

• W2042334626 abstract "The multiple indicator dilution technique was used to study transfer of labeled HCO3- across the hepatocyte membrane in the anesthetized mongrel dog. A bolus of H[14C]O3-, 51Cr-labeled erythrocytes, [36Cl-] and/or [3H]sucrose, and [3H]OH was injected through a catheter in the portal vein, and timed anaerobic blood samples were obtained from a catheter in the hepatic vein. Experiments were carried out in untreated controls and after intravenous infusion of acetazolamide (100 mg/kg). In the controls, the H[14C]O3- curve was very similar to the [3H]OH curve. The dilution curves were all linear transformations of each other, indicating that HCO3-, as had previously been shown for the other diffusible tracers, undergoes delayed-wave flow-limited distribution. The distribution space for H[14C]O3- in the control situation includes the blood plasma and interstitial spaces, the erythrocyte interior modified by a Donnan equilibrium, and the available liver cellular space. The calculated HCO3- concentration in the liver cells was somewhat lower than that in the plasma space; the difference implied a cellular pH lower than that of plasma by approximately 0.08 pH units. When the carbonic anhydrases were inhibited with acetazolamide, the dilution curve for H[14C]O3- changed radically, approaching that for [36Cl-], which does not enter the liver cells. The change indicates that although HCO3-, like Cl-, is rapidly exchanged between plasma and erythrocytes, it also does not readily penetrate hepatocytes unless previously transformed to carbon dioxide by the carbonic anhydrases." @default.
• W2042334626 created "2016-06-24" @default.
• W2042334626 creator A5056114344 @default.
• W2042334626 creator A5061311457 @default.
• W2042334626 creator A5091736216 @default.
• W2042334626 date "1989-12-01" @default.
• W2042334626 modified "2023-09-23" @default.
• W2042334626 title "Handling of tracer bicarbonate by the liver. The relative impermeability of hepatocyte cell membranes to the ionic species." @default.
• W2042334626 cites W1531302136 @default.
• W2042334626 cites W1582739238 @default.
• W2042334626 cites W1592725280 @default.
• W2042334626 cites W1964415651 @default.
• W2042334626 cites W1967028067 @default.
• W2042334626 cites W1970794990 @default.
• W2042334626 cites W1991003128 @default.
• W2042334626 cites W2006346461 @default.
• W2042334626 cites W2018065563 @default.
• W2042334626 cites W2023194874 @default.
• W2042334626 cites W2026516392 @default.
• W2042334626 cites W2028357357 @default.
• W2042334626 cites W2035010120 @default.
• W2042334626 cites W2040969251 @default.
• W2042334626 cites W2049658325 @default.
• W2042334626 cites W2051797919 @default.
• W2042334626 cites W2067103237 @default.
• W2042334626 cites W2071632526 @default.
• W2042334626 cites W2071976999 @default.
• W2042334626 cites W2089379582 @default.
• W2042334626 cites W2111298924 @default.
• W2042334626 cites W2125968048 @default.
• W2042334626 cites W2128263054 @default.
• W2042334626 cites W2170472019 @default.
• W2042334626 cites W2172656403 @default.
• W2042334626 cites W22086273 @default.
• W2042334626 cites W2286810418 @default.
• W2042334626 cites W2338651672 @default.
• W2042334626 cites W2398223916 @default.
• W2042334626 cites W2399287373 @default.
• W2042334626 cites W2402717364 @default.
• W2042334626 cites W2403286610 @default.
• W2042334626 cites W2410626056 @default.
• W2042334626 cites W2414996217 @default.
• W2042334626 cites W2434348108 @default.
• W2042334626 cites W2499043969 @default.
• W2042334626 cites W35637169 @default.
• W2042334626 doi "https://doi.org/10.1161/01.res.65.6.1646" @default.
• W2042334626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2510954" @default.
• W2042334626 hasPublicationYear "1989" @default.
• W2042334626 type Work @default.
• W2042334626 sameAs 2042334626 @default.
• W2042334626 citedByCount "5" @default.
• W2042334626 crossrefType "journal-article" @default.
• W2042334626 hasAuthorship W2042334626A5056114344 @default.
• W2042334626 hasAuthorship W2042334626A5061311457 @default.
• W2042334626 hasAuthorship W2042334626A5091736216 @default.
• W2042334626 hasBestOaLocation W20423346261 @default.
• W2042334626 hasConcept C121332964 @default.
• W2042334626 hasConcept C12554922 @default.
• W2042334626 hasConcept C126322002 @default.
• W2042334626 hasConcept C178790620 @default.
• W2042334626 hasConcept C181199279 @default.
• W2042334626 hasConcept C185592680 @default.
• W2042334626 hasConcept C202751555 @default.
• W2042334626 hasConcept C2775914622 @default.
• W2042334626 hasConcept C2776200302 @default.
• W2042334626 hasConcept C2776557347 @default.
• W2042334626 hasConcept C2777359374 @default.
• W2042334626 hasConcept C2777405951 @default.
• W2042334626 hasConcept C2781112554 @default.
• W2042334626 hasConcept C41625074 @default.
• W2042334626 hasConcept C43376680 @default.
• W2042334626 hasConcept C55493867 @default.
• W2042334626 hasConcept C71924100 @default.
• W2042334626 hasConcept C86803240 @default.
• W2042334626 hasConcept C96618451 @default.
• W2042334626 hasConcept C97355855 @default.
• W2042334626 hasConceptScore W2042334626C121332964 @default.
• W2042334626 hasConceptScore W2042334626C12554922 @default.
• W2042334626 hasConceptScore W2042334626C126322002 @default.
• W2042334626 hasConceptScore W2042334626C178790620 @default.
• W2042334626 hasConceptScore W2042334626C181199279 @default.
• W2042334626 hasConceptScore W2042334626C185592680 @default.
• W2042334626 hasConceptScore W2042334626C202751555 @default.
• W2042334626 hasConceptScore W2042334626C2775914622 @default.
• W2042334626 hasConceptScore W2042334626C2776200302 @default.
• W2042334626 hasConceptScore W2042334626C2776557347 @default.
• W2042334626 hasConceptScore W2042334626C2777359374 @default.
• W2042334626 hasConceptScore W2042334626C2777405951 @default.
• W2042334626 hasConceptScore W2042334626C2781112554 @default.
• W2042334626 hasConceptScore W2042334626C41625074 @default.
• W2042334626 hasConceptScore W2042334626C43376680 @default.
• W2042334626 hasConceptScore W2042334626C55493867 @default.
• W2042334626 hasConceptScore W2042334626C71924100 @default.
• W2042334626 hasConceptScore W2042334626C86803240 @default.
• W2042334626 hasConceptScore W2042334626C96618451 @default.
• W2042334626 hasConceptScore W2042334626C97355855 @default.
• W2042334626 hasLocation W20423346261 @default.
• W2042334626 hasLocation W20423346262 @default.
• W2042334626 hasOpenAccess W2042334626 @default.
• W2042334626 hasPrimaryLocation W20423346261 @default.

• next