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- W2042336005 abstract "We have investigated the regulation of the spontaneously induced in vitro secondary antibody response of rabbit lymph node cells. A vigorous spontaneous IgG response was observed with the synthesis of high avidity antibody. Separation of lymph node cells on glass bead columns into a nonadherent and adherent fraction revealed that the nonadherent fraction yields a spontaneous antibody response which was three to four times greater than the response obtained with unfractionated control cells. The glass bead nonadherent cell response could be inhibited by the addition of either control or adherent cells. Characterization of the adherent cell population suggests that the suppressor cell is a macrophage. This suppressor cell regulates not only the magnitude of the response but the quality of antibody produced. In the absence of suppressor cells, glass bead nonadherent cell cultures give rise to larger numbers of antibody-forming cells producing low avidity antibody." @default.
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- W2042336005 date "1978-09-01" @default.
- W2042336005 modified "2023-10-18" @default.
- W2042336005 title "Suppressor cell regulation of the spontaneously induced in vitro secondary antibody response" @default.
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- W2042336005 doi "https://doi.org/10.1016/0008-8749(78)90314-3" @default.
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