Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042341808> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2042341808 endingPage "137" @default.
- W2042341808 startingPage "132" @default.
- W2042341808 abstract "This report compares the effect of antidepressants on the accumulation of [3H]catecholamines in two human neuroblastoma cell lines, IMR-32 and SK-N-SH, and a rat pheochromocytoma cell line, PC-12. Analysis of the catecholamine uptake system in SK-N-SH cells revealed that both [3H]dopamine and [3H]norepinephrine accumulated via a single competitive, saturable and apparently active process. Similar potencies exhibited by several inhibitors suggest that identical uptake systems exist in all 3 cell lines, with SK-N-SH cells being the most active. Although SK-N-SH and PC-12 cells have been reported to secrete dopamine in preference to other catecholamines, high intracellular concentrations of [3H]norepinephrine were measurable after incubation with [3H]dopamine. Additionally, [3H]norepinephrine/[3H]dopamine ratios increased with longer tracer incubations, in the presence of exogenous ascorbate and when including O-methylated metabolites. Moreover, accumulation of [3H]catechols was competitively inhibited by various antidepressants, with maximal inhibition to 70% of control andKis consistent with reported noradrenergic uptake1 transport systems. Hence, the human neuroblastoma cell lines studied appear to serve as appropriate models of catechol reuptake processes in noradrenergic cells." @default.
- W2042341808 created "2016-06-24" @default.
- W2042341808 creator A5062174660 @default.
- W2042341808 creator A5068828793 @default.
- W2042341808 date "1986-10-01" @default.
- W2042341808 modified "2023-10-11" @default.
- W2042341808 title "Human neuroblastoma cell lines as models of catechol uptake" @default.
- W2042341808 cites W1490334811 @default.
- W2042341808 cites W1546050560 @default.
- W2042341808 cites W1775749144 @default.
- W2042341808 cites W1963989474 @default.
- W2042341808 cites W1965449120 @default.
- W2042341808 cites W1983819303 @default.
- W2042341808 cites W1985024155 @default.
- W2042341808 cites W1998385128 @default.
- W2042341808 cites W2002669946 @default.
- W2042341808 cites W2008052716 @default.
- W2042341808 cites W2027189267 @default.
- W2042341808 cites W2040803902 @default.
- W2042341808 cites W2070539878 @default.
- W2042341808 cites W2084458099 @default.
- W2042341808 cites W2086340893 @default.
- W2042341808 cites W2123403631 @default.
- W2042341808 doi "https://doi.org/10.1016/0006-8993(86)91228-x" @default.
- W2042341808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3790988" @default.
- W2042341808 hasPublicationYear "1986" @default.
- W2042341808 type Work @default.
- W2042341808 sameAs 2042341808 @default.
- W2042341808 citedByCount "54" @default.
- W2042341808 countsByYear W20423418082013 @default.
- W2042341808 countsByYear W20423418082014 @default.
- W2042341808 countsByYear W20423418082015 @default.
- W2042341808 countsByYear W20423418082019 @default.
- W2042341808 crossrefType "journal-article" @default.
- W2042341808 hasAuthorship W2042341808A5062174660 @default.
- W2042341808 hasAuthorship W2042341808A5068828793 @default.
- W2042341808 hasConcept C126322002 @default.
- W2042341808 hasConcept C134018914 @default.
- W2042341808 hasConcept C170493617 @default.
- W2042341808 hasConcept C185592680 @default.
- W2042341808 hasConcept C2775864247 @default.
- W2042341808 hasConcept C2775894120 @default.
- W2042341808 hasConcept C2776715637 @default.
- W2042341808 hasConcept C2777713698 @default.
- W2042341808 hasConcept C2778514916 @default.
- W2042341808 hasConcept C513476851 @default.
- W2042341808 hasConcept C54355233 @default.
- W2042341808 hasConcept C55493867 @default.
- W2042341808 hasConcept C71924100 @default.
- W2042341808 hasConcept C79879829 @default.
- W2042341808 hasConcept C81885089 @default.
- W2042341808 hasConcept C86803240 @default.
- W2042341808 hasConcept C99631742 @default.
- W2042341808 hasConceptScore W2042341808C126322002 @default.
- W2042341808 hasConceptScore W2042341808C134018914 @default.
- W2042341808 hasConceptScore W2042341808C170493617 @default.
- W2042341808 hasConceptScore W2042341808C185592680 @default.
- W2042341808 hasConceptScore W2042341808C2775864247 @default.
- W2042341808 hasConceptScore W2042341808C2775894120 @default.
- W2042341808 hasConceptScore W2042341808C2776715637 @default.
- W2042341808 hasConceptScore W2042341808C2777713698 @default.
- W2042341808 hasConceptScore W2042341808C2778514916 @default.
- W2042341808 hasConceptScore W2042341808C513476851 @default.
- W2042341808 hasConceptScore W2042341808C54355233 @default.
- W2042341808 hasConceptScore W2042341808C55493867 @default.
- W2042341808 hasConceptScore W2042341808C71924100 @default.
- W2042341808 hasConceptScore W2042341808C79879829 @default.
- W2042341808 hasConceptScore W2042341808C81885089 @default.
- W2042341808 hasConceptScore W2042341808C86803240 @default.
- W2042341808 hasConceptScore W2042341808C99631742 @default.
- W2042341808 hasIssue "1" @default.
- W2042341808 hasLocation W20423418081 @default.
- W2042341808 hasLocation W20423418082 @default.
- W2042341808 hasOpenAccess W2042341808 @default.
- W2042341808 hasPrimaryLocation W20423418081 @default.
- W2042341808 hasRelatedWork W1447794348 @default.
- W2042341808 hasRelatedWork W1976295504 @default.
- W2042341808 hasRelatedWork W1978260601 @default.
- W2042341808 hasRelatedWork W2040001135 @default.
- W2042341808 hasRelatedWork W2042233029 @default.
- W2042341808 hasRelatedWork W2042438130 @default.
- W2042341808 hasRelatedWork W2119512662 @default.
- W2042341808 hasRelatedWork W2173961377 @default.
- W2042341808 hasRelatedWork W2260393865 @default.
- W2042341808 hasRelatedWork W2952105427 @default.
- W2042341808 hasVolume "384" @default.
- W2042341808 isParatext "false" @default.
- W2042341808 isRetracted "false" @default.
- W2042341808 magId "2042341808" @default.
- W2042341808 workType "article" @default.