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• W2042346533 abstract "Evidence suggests that stress increases alcohol drinking and promotes relapse in humans. Animal models that assess related behaviors include the sipper tube ethanol self-administration and the stress-induced reinstatement paradigms. While selectively bred for the same high-ethanol-drinking behavior, alcohol-preferring P rats appear to show greater sensitivity to ethanol reinforcement than high-alcohol-drinking HAD rats. The present experiment tested the effects of the pharmacological stressor, yohimbine, on the motivation to seek and consume ethanol implementing a combined sipper tube/reinstatement model using male P and HAD-2 rats. Following training to self-administer ethanol using the sipper tube procedure, rats were tested for the effects of yohimbine (0.625–2.5 mg/kg) on ethanol drinking. Subsequently, rats were tested for the effects of 1.25 mg/kg yohimbine on reinstatement of ethanol seeking. Yohimbine (0.625 and 1.25 mg/kg) increased ethanol self-administration, and the latter dose also decreased latency to complete the response requirement. Yohimbine elicited reinstatement of ethanol seeking in both lines. HAD-2 rats drank more ethanol, but showed similar responding on the ethanol-associated lever compared to P rats. These findings extend both the reinstatement and sipper tube models and justify further exploration of this unique combined paradigm. Despite prior evidence suggesting that P rats are more motivated to seek and consume ethanol, differences in these behaviors between P and HAD-2 rats were not systematic in the present experiment. Further investigation may elucidate whether either selected line may be more sensitive than other selectively bred or outbred rats to stress-related changes in ethanol's reinforcing effects." @default.
• W2042346533 created "2016-06-24" @default.
• W2042346533 creator A5045884851 @default.
• W2042346533 creator A5076132667 @default.
• W2042346533 creator A5085682801 @default.
• W2042346533 date "2013-02-01" @default.
• W2042346533 modified "2023-09-24" @default.
• W2042346533 title "Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats" @default.
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• W2042346533 doi "https://doi.org/10.1016/j.bbr.2012.10.030" @default.
• W2042346533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3513579" @default.
• W2042346533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23103404" @default.
• W2042346533 hasPublicationYear "2013" @default.
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