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• W2042348767 abstract "(Received: June 14, 2014; Revised: October 24, 2014; Accepted: November 5, 2014)Abstract : Klotho deficiency is an early event in acute kidney injury (AKI) that exacerbates acute kidney damage.The present study explored the expression of Klotho and inflammation related factors in cisplatin-induced AKI. Rats(n = 18) were treated with cisplatin intraperitoneal injection (5 mg/kg) or left untreated as controls (n = 6), then sacrificedat 5 (n = 6) and 10 days (n = 6) treatment. Five days after cisplatin injection, the serum kidney enzymes and kidneycell apoptosis were significantly increased. Moreover, the expression of Klotho was decreased when compared to thecontrol group, especially in the cortex and outer medulla regions. In contrast, inflammation related signals includingnuclear factor kappa B, tumor necrosis factor-α, and tumor necrosis factor-like weak inducer of apoptosis were enhanced.However, 10 days after cisplatin injection, Klotho expression was enhanced upon both IHC and Western blot analysis,with slightly recovered renal function and decreased apoptosis. Furthermore, inflammation related signals expressionwas decreased relative to the 5 days group. Overall, this study confirmed the opposite expression patterns betweenKlotho and inflammation related signals and their localization in cisplatin-induced AKI kidney. Keywords: acute kidney injury, inflammatory cytokine, Klotho, localization" @default.
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• W2042348767 date "2014-12-31" @default.
• W2042348767 modified "2023-10-14" @default.
• W2042348767 title "Localization of Klotho in cisplatin induced acute kidney failure" @default.
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• W2042348767 doi "https://doi.org/10.14405/kjvr.2014.54.4.225" @default.
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