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- W2042352160 abstract "Background: Chronic exposure to high levels of free fatty acid (FFA) has adverse effects on the function of pancreatic beta-cell, with a consequent increase in the production of reactive oxygen species. Poly (ADP-Ribose) polymerase (PARP-1) overactivation leads to massive NAD+ consumption and ATP depletion with induction of cellular necrosis under high reactive oxygen species. In the present study, we investigated whether inhibitors of poly(ADP-ribose) polymerase were capable of protecting beta-cells from death induced by extended exposure to FFA." @default.
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- W2042352160 date "2009-06-09" @default.
- W2042352160 modified "2023-09-25" @default.
- W2042352160 title "Roles of Inhibitors of Poly(ADP-ribose) Polymerase in Protecting Rat RINm5F Cell Line against Free Fatty Acid-induced Apoptosis" @default.
- W2042352160 doi "https://doi.org/10.1055/s-0029-1202794" @default.
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