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- W2042353552 abstract "To test the effect in normal human volunteers of transient systemic inflammation on the variability in time-series behaviors of widely divergent physiologic measures of the human inflammatory response.Prospective study of human volunteers who were tested on 2 consecutive days, a control day and a treatment day. Each participant served as his or her own control.Critical care facility of a university medical center.Subjects were eight healthy human volunteers.Participant subjects were tested on both a baseline day with no intervention and on a treatment day when they received 4 ng/kg intravenous Escherichia coli endotoxin.Continuous electrocardiographic recordings and serial blood sampling (performed every 5 mins) were used to create time-series of heart rate (R-R intervals), neutrophil function (phagocytosis), and plasma cortisol concentrations. For each primary measure, we recorded a significant increase in the regularity (decreased variability) of the functional measurement as assessed by the statistical entity, approximate entropy.Increased regularity, or decreased variability, of organ functions is a generalized response to systemic inflammation that occurs in widely divergent systems during endotoxemia." @default.
- W2042353552 created "2016-06-24" @default.
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- W2042353552 date "2005-03-01" @default.
- W2042353552 modified "2023-09-30" @default.
- W2042353552 title "Decreased physiologic variability as a generalized response to human endotoxemia*" @default.
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- W2042353552 doi "https://doi.org/10.1097/01.ccm.0000155908.46346.ed" @default.
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