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• W2042360898 abstract "<b>Background and Aims:</b> The <i>Helicobacter pylori CagA</i> gene is a major virulence factor that plays an important role in gastric pathologies. The size variation of <i>CagA</i> gene, which is dependent on the 3' repeat region, contains one or more Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs and <i>CagA</i> multimerization (CM) motifs. Four segments flanking the EPIYA motifs, EPIYA −A, −B, −C, or −D, were reported to play a crucial role in the pathogenesis of <i>H. pylori</i> infection. The aim was to determine the roles of EPIYA segments and CM motifs in gastroduodenal pathogenesis in an Iraqi population. <b>Patients and Methods:</b> Gastric biopsies were collected from 210 patients with gastritis, duodenal ulcer (DU), gastric ulcer (GU), and gastric cancer (GC). The EPIYA motif genotyping was determined by polymerase chain reaction and sequencing. The differences in age, gender, and <i>CagA</i> EPIYA motifs of <i>H. pylori</i> between GC, DU, GU and gastritis patients were analyzed using a χ ² -test. <b>Results</b> : A total of 22 (45.8%) strains had three copies of EPIYA (ABC type), 2 (4.16%) had four copies (ABCC type), 6 (12.7%) had five copies (ABCCC type), 13 (27.08%) had two copies (AB type), 3 (6.25%) had the BC, and 2 (4.17%) had AC motif. The alignment of the deduced protein sequences confirmed that there were no East Asian type EPIYA-D sequences in Iraqi strains. A significant association was found between increase in number of EPIYA-C motifs and GU (<i>P</i> ≤ 0.01) compared with gastritis. <b>Conclusions:</b> The structure of the 3' region of the <i>CagA</i> gene in Iraqi strains was Western type with a variable number of EPIYA-C and CM motifs. A significant association was found between increase in number of EPIYA-C motifs and GU compared with gastritis indicating predictive association with the severity of the disease. The GenBank accession numbers for the partial <i>CagA</i> nucleotide sequences determined in this study are JX164093-JX164112." @default.
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• W2042360898 date "2013-01-01" @default.
• W2042360898 modified "2023-10-18" @default.
• W2042360898 title "Study of the cytoxin-associated gene a (CagA gene) in Helicobacter pylori using gastric biopsies of Iraqi patients" @default.
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• W2042360898 doi "https://doi.org/10.4103/1319-3767.108474" @default.
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