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- W2042361735 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCLipocalin 2 (Lcn2) has long been regarded to induce cellular proliferation because expression of Lcn2 has been associated in a variety of proliferative cells. Consistent with this, it has been demonstrated in the present study that Lcn2 was significantly elevated in human HCC (hepatocellular carcinoma) tissues compared with the non-tumor liver tissues. However, the roles of Lcn2 in hepatocarcinogenesis are far from clear. To investigate the effects of Lcn2 expression on the hepatocarcinogenesis, Chang liver and SK-Hep1, the HCC cell lines, were genetically manipulated to express Lcn2 and their effects on the proliferation and invasion of HCC cells were analyzed. Ectopic expression of Lcn2 in HCC cells significantly inhibited the growth of HCC cells in vitro and in vivo. In addition, its expression reduced the invasive potential of cells and inhibited the expression of matrix metalloproteinase 2 (MMP-2). Lcn2 may exert its function partly through the inhibition of the c-Jun N-terminal kinase (JNK) and phosphatidyl inositol 3′-kinase (PI3K)/Akt signaling pathways in HCC cells, since selective inhibition of those pathways using pharmacological inhibitors significantly inhibited the proliferation, invasion and MMP-2 expression, whereas Lcn2 expression suppressed the JNK and PI3K/Akt pathways. In conclusion, these results clearly indicate that Lcn2 may play a protective role in the progression of HCCs by suppressing the proliferation and invasion of HCC cells, although clinical significance of the present findings remains to be evaluated.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-12." @default.
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- W2042361735 date "2010-04-15" @default.
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- W2042361735 title "Abstract LB-12: Inhibition of the proliferation and invasion of hepatocellular carcinoma cells by lipocalin 2 through blockade of JNK and PI3K/Akt signaling" @default.
- W2042361735 doi "https://doi.org/10.1158/1538-7445.am10-lb-12" @default.
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