FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042362376> ?p ?o ?g. }

• W2042362376 endingPage "281" @default.
• W2042362376 startingPage "265" @default.
• W2042362376 abstract "Non-alcoholic steatohepatitis (NASH) is the hepatic manifestation of metabolic syndrome that is characterized by steatosis, inflammation, and fibrosis, and may progress to cirrhosis and carcinoma. To investigate its pathogenic processes, we established a novel murine model for NASH by combination of a high-fat diet (HFD) and oxidized low-density lipoprotein (oxLDL). Mice that received HFD for 23 weeks showed hepatic steatosis, slight fibrosis, and a high level of lipid peroxidation compared with a regular diet (RD)-fed mice. Hepatic injury and elevated tumor necrosis factor (TNF)-α mRNA expression were also detected in these mice. Moreover, oxLDL administration to HFD-fed mice during weeks 21–23 not only aggravated hepatic steatosis, fibrosis, and lipid metabolism, but also resulted in intense inflammation, including severe hepatic injury and inflammatory cell infiltration, which are the typical histological features of NASH. Inflammation was accompanied by increased gene expression of TNF-α and interleukin (IL)-6. Additionally, the livers of RD-fed animals treated with oxLDL during weeks 21–23 were characterized by foamy macrophages and inflammatory cell infiltration along with an elevated IL-6 mRNA level. These results suggest that an increased oxidative state, including HFD-induced intracellular lipid peroxidation and its extracellular source from oxLDL, is the actual trigger for hepatic inflammation in which liver injury is mediated by TNF-α and inflammatory cell accumulation is dependent on IL-6. HFD and oxLDL also induced insulin resistance in mice; additionally, oxLDL downregulated insulin secretion. In this model, CD36 overexpression was observed in the hepatocytes of HFD-fed mice and those treated with HFD and oxLDL, and in the hepatic macrophages of RD-fed mice immediately after oxLDL treatment. In vitro experiments indicated a rapid and transient elevation of CD36 on macrophage plasma membrane in response to oxLDL. Our findings demonstrate that CD36 expressed on hepatocytes and hepatic macrophages mediates the pathophysiology of NASH." @default.
• W2042362376 created "2016-06-24" @default.
• W2042362376 creator A5017240065 @default.
• W2042362376 creator A5028165423 @default.
• W2042362376 creator A5041702299 @default.
• W2042362376 creator A5044131429 @default.
• W2042362376 creator A5046528941 @default.
• W2042362376 creator A5047982024 @default.
• W2042362376 creator A5048416506 @default.
• W2042362376 creator A5061213634 @default.
• W2042362376 creator A5084153953 @default.
• W2042362376 date "2012-02-01" @default.
• W2042362376 modified "2023-10-11" @default.
• W2042362376 title "A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein" @default.
• W2042362376 cites W1480164748 @default.
• W2042362376 cites W1515681057 @default.
• W2042362376 cites W1523155649 @default.
• W2042362376 cites W1570902349 @default.
• W2042362376 cites W1723158139 @default.
• W2042362376 cites W1910361842 @default.
• W2042362376 cites W1963672344 @default.
• W2042362376 cites W1969200048 @default.
• W2042362376 cites W1974974158 @default.
• W2042362376 cites W1975537939 @default.
• W2042362376 cites W1975905715 @default.
• W2042362376 cites W1978805605 @default.
• W2042362376 cites W1987547292 @default.
• W2042362376 cites W2004063453 @default.
• W2042362376 cites W2004160850 @default.
• W2042362376 cites W2010480924 @default.
• W2042362376 cites W2019048359 @default.
• W2042362376 cites W2025795822 @default.
• W2042362376 cites W2028658648 @default.
• W2042362376 cites W2031423487 @default.
• W2042362376 cites W2038028850 @default.
• W2042362376 cites W2047257800 @default.
• W2042362376 cites W2054208989 @default.
• W2042362376 cites W2056888748 @default.
• W2042362376 cites W2057002702 @default.
• W2042362376 cites W2058301937 @default.
• W2042362376 cites W2066132276 @default.
• W2042362376 cites W2067740038 @default.
• W2042362376 cites W2068793226 @default.
• W2042362376 cites W2069732290 @default.
• W2042362376 cites W2070769983 @default.
• W2042362376 cites W2083686252 @default.
• W2042362376 cites W2084776235 @default.
• W2042362376 cites W2086133390 @default.
• W2042362376 cites W2088285453 @default.
• W2042362376 cites W2089264179 @default.
• W2042362376 cites W2092412521 @default.
• W2042362376 cites W2093709010 @default.
• W2042362376 cites W2094941678 @default.
• W2042362376 cites W2096265917 @default.
• W2042362376 cites W2104024176 @default.
• W2042362376 cites W2105676684 @default.
• W2042362376 cites W2114199165 @default.
• W2042362376 cites W2122742700 @default.
• W2042362376 cites W2124664603 @default.
• W2042362376 cites W2128594838 @default.
• W2042362376 cites W2130618859 @default.
• W2042362376 cites W2132739516 @default.
• W2042362376 cites W2137506791 @default.
• W2042362376 cites W2138774651 @default.
• W2042362376 cites W2144178804 @default.
• W2042362376 cites W2148586088 @default.
• W2042362376 cites W2164118055 @default.
• W2042362376 cites W2168526937 @default.
• W2042362376 cites W2170512054 @default.
• W2042362376 doi "https://doi.org/10.1038/labinvest.2011.159" @default.
• W2042362376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22064320" @default.
• W2042362376 hasPublicationYear "2012" @default.
• W2042362376 type Work @default.
• W2042362376 sameAs 2042362376 @default.
• W2042362376 citedByCount "53" @default.
• W2042362376 countsByYear W20423623762012 @default.
• W2042362376 countsByYear W20423623762013 @default.
• W2042362376 countsByYear W20423623762014 @default.
• W2042362376 countsByYear W20423623762015 @default.
• W2042362376 countsByYear W20423623762016 @default.
• W2042362376 countsByYear W20423623762017 @default.
• W2042362376 countsByYear W20423623762018 @default.
• W2042362376 countsByYear W20423623762019 @default.
• W2042362376 countsByYear W20423623762020 @default.
• W2042362376 countsByYear W20423623762021 @default.
• W2042362376 countsByYear W20423623762022 @default.
• W2042362376 countsByYear W20423623762023 @default.
• W2042362376 crossrefType "journal-article" @default.
• W2042362376 hasAuthorship W2042362376A5017240065 @default.
• W2042362376 hasAuthorship W2042362376A5028165423 @default.
• W2042362376 hasAuthorship W2042362376A5041702299 @default.
• W2042362376 hasAuthorship W2042362376A5044131429 @default.
• W2042362376 hasAuthorship W2042362376A5046528941 @default.
• W2042362376 hasAuthorship W2042362376A5047982024 @default.
• W2042362376 hasAuthorship W2042362376A5048416506 @default.
• W2042362376 hasAuthorship W2042362376A5061213634 @default.
• W2042362376 hasAuthorship W2042362376A5084153953 @default.
• W2042362376 hasBestOaLocation W20423623761 @default.

• next