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• W2042369211 startingPage "1261" @default.
• W2042369211 abstract "Methylation of cytosines in DNA is important for the regulation of expression of many genes. During carcinogenesis, normal patterns of gene methylation can be altered. Oxygen radical injury, shown to damage DNA in a variety of ways associated with cancer development and other conditions, has been suggested to affect DNA methylation, but a mechanism has not been demonstrated. Using oligonucleotides containing the common oxygen radical adduct 8-hydroxyguanine to replace guanine, we found that the enzymatic methylation of adjacent cytosines is profoundly altered. Furthermore, there is a high degree of positional specificity with respect to this effect. Thus, free radical injury may explain some of the altered methylation observed during carcinogenesis." @default.
• W2042369211 created "2016-06-24" @default.
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• W2042369211 date "1994-02-15" @default.
• W2042369211 modified "2023-10-14" @default.
• W2042369211 title "Free radical adducts induce alterations in DNAcytosine methylation." @default.
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• W2042369211 doi "https://doi.org/10.1073/pnas.91.4.1261" @default.
• W2042369211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/43137" @default.
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