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• W2042378638 endingPage "e93897" @default.
• W2042378638 startingPage "e93897" @default.
• W2042378638 abstract "Major- and minor-group human rhinoviruses (HRV) enter their host by binding to the cell surface molecules ICAM-1 and LDL-R, respectively, which are present on both macrophages and epithelial cells. Although epithelial cells are the primary site of productive HRV infection, previous studies have implicated macrophages in establishing the cytokine dysregulation that occurs during rhinovirus-induced asthma exacerbations. Analysis of the transcriptome of primary human macrophages exposed to major- and minor-group HRV demonstrated differential gene expression. Alterations in gene expression were traced to differential mitochondrial activity and signaling pathway activation between two rhinovirus serotypes, HRV16 (major-group) and HRV1A (minor-group), upon initial HRV binding. Variances in phosphorylation of kinases (p38, JNK, ERK5) and transcription factors (ATF-2, CREB, CEBP-alpha) were observed between the major- and minor-group HRV treatments. Differential activation of signaling pathways led to changes in the production of the asthma-relevant cytokines CCL20, CCL2, and IL-10. This is the first report of genetically similar viruses eliciting dissimilar cytokine release, transcription factor phosphorylation, and MAPK activation from macrophages, suggesting that receptor use is a mechanism for establishing the inflammatory microenvironment in the human airway upon exposure to rhinovirus." @default.
• W2042378638 created "2016-06-24" @default.
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• W2042378638 date "2014-04-15" @default.
• W2042378638 modified "2023-10-16" @default.
• W2042378638 title "Major and Minor Group Rhinoviruses Elicit Differential Signaling and Cytokine Responses as a Function of Receptor-Mediated Signal Transduction" @default.
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• W2042378638 doi "https://doi.org/10.1371/journal.pone.0093897" @default.
• W2042378638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3988043" @default.
• W2042378638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24736642" @default.
• W2042378638 hasPublicationYear "2014" @default.
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