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- W2042394032 abstract "Regenerating (Reg) protein has a trophic effect on gastric mucosal cells. We have shown that Reg gene expression is increased in enterochromaffin-like (ECL) cells during the healing of damaged gastric mucosa around mucosal erosion. This study was designed to explore the stimulants of Reg expression during the healing of gastric mucosal damage.Time course changes of the expression of genes for various proinflammatory cytokines and Reg were investigated after induction of gastric mucosal lesions in rats. The direct effect of proinflammatory cytokines on Reg gene expression and Reg protein production were investigated in vitro using counterflow elutriation-enriched rat ECL cells. CXC receptor 2 (CXCR-2) expression was investigated in ECL cells by reverse-transcription polymerase chain reaction. Reg gene expression was also investigated in rats treated by the neutralizing antibody of cytokine-induced neutrophil chemoattractant (CINC-2 beta).During healing, the gene expression of several proinflammatory cytokines and Reg was markedly augmented. Among the proinflammatory cytokines, CINC-2 beta is the only cytokine in which augmented expression preceded the increase of Reg gene expression. In rats treated with CINC-2 beta neutralizing antibody, the augmentation of Reg gene expression was significantly inhibited. When ECL cells were incubated with these proinflammatory cytokines, CINC-2 beta dose-dependently increased Reg messenger RNA and Reg protein in ECL cells. CXCR-2 was identified in isolated ECL cells.CINC-2 beta, expressed in damaged gastric mucosa, stimulates the production of Reg protein in ECL cells via CXCR-2 and may be involved in the accelerated healing of injured gastric mucosa." @default.
- W2042394032 created "2016-06-24" @default.
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- W2042394032 date "2000-12-01" @default.
- W2042394032 modified "2023-10-10" @default.
- W2042394032 title "Neutrophil chemoattractant 2β regulates expression of the Reg gene in injured gastric mucosa in rats" @default.
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- W2042394032 cites W1557734333 @default.
- W2042394032 cites W17233147 @default.
- W2042394032 cites W1881509706 @default.
- W2042394032 cites W196234132 @default.
- W2042394032 cites W1969410251 @default.
- W2042394032 cites W1973297164 @default.
- W2042394032 cites W1975034079 @default.
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- W2042394032 cites W1984232970 @default.
- W2042394032 cites W1985363141 @default.
- W2042394032 cites W1986323183 @default.
- W2042394032 cites W1993039412 @default.
- W2042394032 cites W1993703800 @default.
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- W2042394032 doi "https://doi.org/10.1053/gast.2000.20262" @default.
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