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• W2042394891 abstract "It has long been speculated that metabolites, produced by gut microbiota, influence host metabolism in health and diseases. Here, we reveal that indole, a metabolite produced from the dissimilation of tryptophan, is able to modulate the secretion of glucagon-like peptide-1 (GLP-1) from immortalized and primary mouse colonic L cells. Indole increased GLP-1 release during short exposures, but it reduced secretion over longer periods. These effects were attributed to the ability of indole to affect two key molecular mechanisms in L cells. On the one hand, indole inhibited voltage-gated K+ channels, increased the temporal width of action potentials fired by L cells, and led to enhanced Ca2+ entry, thereby acutely stimulating GLP-1 secretion. On the other hand, indole slowed ATP production by blocking NADH dehydrogenase, thus leading to a prolonged reduction of GLP-1 secretion. Our results identify indole as a signaling molecule by which gut microbiota communicate with L cells and influence host metabolism." @default.
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• W2042394891 date "2014-11-01" @default.
• W2042394891 modified "2023-10-18" @default.
• W2042394891 title "Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells" @default.
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• W2042394891 doi "https://doi.org/10.1016/j.celrep.2014.10.032" @default.
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