FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042396499> ?p ?o ?g. }

• W2042396499 abstract "GDP-mannose:inositol-phosphorylceramide (MIPC)-derived glycosphingolipids are important pathogen-associated molecular patterns (PAMP) of Candida albicans and according to recently published data also of Aspergillus fumigatus. MIPC transferases are essential for the synthesis of MIPC, but have so far been studied only in Saccharomyces cerevisiae and C. albicans. Here, we have identified MitA as the only MIPC transferase in A. fumigatus. The DeltamitA mutant lacks MIPC and MIPC-derived glycosphingolipids and accumulates the precursor IPC. The mutant grows normally, shows no defects in cell wall or membrane organization and a normal resistance to different stressors. It is, however, sensitive to high Ca(2+) concentrations, especially during germination. Germination of DeltamitA mutant conidia is also decelerated under normal growth conditions, but neither the virulence of this mutant in a systemic model of infection nor its ability to trigger a cytokine response in macrophages is impaired, arguing against a role of MIPC-derived glycosphingolipids as important A. fumigatus PAMPs." @default.
• W2042396499 created "2016-06-24" @default.
• W2042396499 creator A5000829320 @default.
• W2042396499 creator A5005331384 @default.
• W2042396499 creator A5009942587 @default.
• W2042396499 creator A5016986473 @default.
• W2042396499 creator A5024605820 @default.
• W2042396499 creator A5050574976 @default.
• W2042396499 creator A5051150623 @default.
• W2042396499 creator A5061433515 @default.
• W2042396499 creator A5082450306 @default.
• W2042396499 creator A5084496232 @default.
• W2042396499 date "2010-02-01" @default.
• W2042396499 modified "2023-09-26" @default.
• W2042396499 title "The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity" @default.
• W2042396499 cites W1572283658 @default.
• W2042396499 cites W1574036889 @default.
• W2042396499 cites W1965897811 @default.
• W2042396499 cites W1988940275 @default.
• W2042396499 cites W1995380559 @default.
• W2042396499 cites W1996836394 @default.
• W2042396499 cites W2021311755 @default.
• W2042396499 cites W2022075663 @default.
• W2042396499 cites W2022483954 @default.
• W2042396499 cites W2026240439 @default.
• W2042396499 cites W2029693312 @default.
• W2042396499 cites W2053505134 @default.
• W2042396499 cites W2059037690 @default.
• W2042396499 cites W2077099598 @default.
• W2042396499 cites W2099905667 @default.
• W2042396499 cites W2100585044 @default.
• W2042396499 cites W2101347093 @default.
• W2042396499 cites W2102238970 @default.
• W2042396499 cites W2107902741 @default.
• W2042396499 cites W2121211481 @default.
• W2042396499 cites W2126287353 @default.
• W2042396499 cites W2128025573 @default.
• W2042396499 cites W2138253605 @default.
• W2042396499 cites W2148251929 @default.
• W2042396499 cites W2151673476 @default.
• W2042396499 cites W2153911335 @default.
• W2042396499 cites W2160173406 @default.
• W2042396499 doi "https://doi.org/10.1016/j.fgb.2009.10.001" @default.
• W2042396499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19822220" @default.
• W2042396499 hasPublicationYear "2010" @default.
• W2042396499 type Work @default.
• W2042396499 sameAs 2042396499 @default.
• W2042396499 citedByCount "24" @default.
• W2042396499 countsByYear W20423964992012 @default.
• W2042396499 countsByYear W20423964992014 @default.
• W2042396499 countsByYear W20423964992015 @default.
• W2042396499 countsByYear W20423964992016 @default.
• W2042396499 countsByYear W20423964992017 @default.
• W2042396499 countsByYear W20423964992018 @default.
• W2042396499 countsByYear W20423964992019 @default.
• W2042396499 countsByYear W20423964992020 @default.
• W2042396499 countsByYear W20423964992021 @default.
• W2042396499 countsByYear W20423964992022 @default.
• W2042396499 countsByYear W20423964992023 @default.
• W2042396499 crossrefType "journal-article" @default.
• W2042396499 hasAuthorship W2042396499A5000829320 @default.
• W2042396499 hasAuthorship W2042396499A5005331384 @default.
• W2042396499 hasAuthorship W2042396499A5009942587 @default.
• W2042396499 hasAuthorship W2042396499A5016986473 @default.
• W2042396499 hasAuthorship W2042396499A5024605820 @default.
• W2042396499 hasAuthorship W2042396499A5050574976 @default.
• W2042396499 hasAuthorship W2042396499A5051150623 @default.
• W2042396499 hasAuthorship W2042396499A5061433515 @default.
• W2042396499 hasAuthorship W2042396499A5082450306 @default.
• W2042396499 hasAuthorship W2042396499A5084496232 @default.
• W2042396499 hasConcept C104317684 @default.
• W2042396499 hasConcept C143065580 @default.
• W2042396499 hasConcept C145081991 @default.
• W2042396499 hasConcept C170493617 @default.
• W2042396499 hasConcept C2777427919 @default.
• W2042396499 hasConcept C2777576037 @default.
• W2042396499 hasConcept C2779222958 @default.
• W2042396499 hasConcept C2779787849 @default.
• W2042396499 hasConcept C2779959462 @default.
• W2042396499 hasConcept C2780917455 @default.
• W2042396499 hasConcept C55493867 @default.
• W2042396499 hasConcept C60987743 @default.
• W2042396499 hasConcept C86803240 @default.
• W2042396499 hasConcept C89423630 @default.
• W2042396499 hasConcept C95444343 @default.
• W2042396499 hasConceptScore W2042396499C104317684 @default.
• W2042396499 hasConceptScore W2042396499C143065580 @default.
• W2042396499 hasConceptScore W2042396499C145081991 @default.
• W2042396499 hasConceptScore W2042396499C170493617 @default.
• W2042396499 hasConceptScore W2042396499C2777427919 @default.
• W2042396499 hasConceptScore W2042396499C2777576037 @default.
• W2042396499 hasConceptScore W2042396499C2779222958 @default.
• W2042396499 hasConceptScore W2042396499C2779787849 @default.
• W2042396499 hasConceptScore W2042396499C2779959462 @default.
• W2042396499 hasConceptScore W2042396499C2780917455 @default.
• W2042396499 hasConceptScore W2042396499C55493867 @default.
• W2042396499 hasConceptScore W2042396499C60987743 @default.
• W2042396499 hasConceptScore W2042396499C86803240 @default.
• W2042396499 hasConceptScore W2042396499C89423630 @default.
• W2042396499 hasConceptScore W2042396499C95444343 @default.

• next