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- W2042397730 abstract "E proteins are basic helix-loop-helix transcription factors that regulate many key aspects of lymphocyte development. Thymocytes express multiple E proteins that are thought to provide cooperative and compensatory functions crucial for T cell differentiation. Contrary to that, we report here that the E protein HEB was uniquely required at the CD4(+)CD8(+) double-positive (DP) stage of T cell development. Thymocytes lacking HEB showed impaired survival, failed to make rearrangements of variable-alpha (V(alpha)) segments to distal joining-alpha (J(alpha)) segments in the gene encoding the T cell antigen receptor alpha-chain (Tcra) and had a profound, intrinsic block in the development of invariant natural killer T cells (iNKT cells) at their earliest progenitor stage. Thus, our results show that HEB is a specific and essential factor in T cell development and in the generation of the iNKT cell lineage, defining a unique role for HEB in the regulation of lymphocyte maturation." @default.
- W2042397730 created "2016-06-24" @default.
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- W2042397730 date "2010-02-14" @default.
- W2042397730 modified "2023-10-17" @default.
- W2042397730 title "An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells" @default.
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- W2042397730 doi "https://doi.org/10.1038/ni.1845" @default.
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