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- W2042397972 abstract "The present study was conducted to determine whether cutaneous itch involves mu-opioid receptors in either of the spinal cord or lower brainstem or in both regions in mice. An intraplantar injection of serotonin hydrochloride (100 nmol/site) induced biting, an itch-related behavior. The behavior was inhibited by subcutaneous (0.3—1 mg/kg) and intracisternal (1—10 nmol/site), but not intrathecal (1—10 nmol/site), injections of naloxone hydrochloride. An intradermal injection of serotonin (100 nmol/site) to the rostral back induced scratching, an itch-related behavior, which was inhibited by subcutaneous (1 mg/kg) and intracisternal (10 nmol/site) injections of naloxone. These results suggest that mu-opioid receptor in the lower brainstem, but not spinal cord, is a site of central pruritogenic action of opioids and is involved in the facilitatory regulation of itch signaling." @default.
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- W2042397972 date "2008-01-01" @default.
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- W2042397972 title "Intracisternal, But Not Intrathecal, Injection of Naloxone Inhibits Cutaneous Itch-Related Response in Mice" @default.
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- W2042397972 doi "https://doi.org/10.1248/bpb.31.2143" @default.
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