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- W204241429 abstract "Objective To investigate the correlation of levels of leptin,IL-1,IL-10 and TNF-α with pregnancy induced hypertension.Methods Hypertension in pregnant rats were induced by injection of L-NAME.Blood pressure was recorded,furthermore the levels of urine protein,serum urea nitrogen,IL-1,IL-10 and TNF-α as well as leptin were detected.Results Pregnancy induced hypertension caused a high level of urine protein and serum urea nitrogen(P 0.01).Moreover,the levels of serum leptin,IL-1 and TNF-αconcentrations were increased significantly(P0.01),on the other hand,the level of serum IL-10 concentration reduced significantly(P 0.05).In addition,there was a positive correlation between levels of serum leptin and the levels of IL-1 and TNF-α,respectively,while a negative correlation between level of serum leptin and that of IL-10 was observed.Conclusion The changes and the interactions between leptin and cytokines might play an important role in the pathogenesis of pregnancy induced hypertension." @default.
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- W204241429 date "2009-01-01" @default.
- W204241429 modified "2023-09-27" @default.
- W204241429 title "The relationship between leptin, cytokines and the pregnancy induced hypertension" @default.
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