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- W2042421580 abstract "Generating a comprehensive understanding of osteogenesis-related gene profiles is very important in the development of new treatments for osteopenic conditions. Developing calvaria undergoes a typical intramembranous bone-forming process. To identify genes associated with osteoblast differentiation, we isolated total RNAs from parietal bones, that represent active osteoblasts, and sutural mesenchyme, that represents osteoprogenitor cells, and comprehensively analyzed their gene expression profiles using an oligo-based Affymetrix microarray chip containing 22,690 probes. About 2100 genes with “Present” calls had more than 2-fold higher expression in bone compared to sutures while 73 of these genes had more than 8-fold expression. Some of these genes are already known to be bone-related biomarkers: VitD receptor, bone sialoprotein, osteocalcin, osteopontin, MMP13, etc. Eight genes were selected and subjected to confirmation by quantitative real-time RT-PCR analyses. All the genes tested showed higher expression in bones, ranging from 5- to 140-fold. Several of these genes are ESTs while others are already known but their functions in osteogenesis were not previously known. Most genes of the BMP and FGF families probed in the Genchip analysis were more highly expressed in bone tissues compared to suture. All differentially-expressed Runx and Dlx family genes also showed higher expression in bone. These results imply that our data is valid and can be used as a good standard for the mining of osteogenesis-related genes." @default.
- W2042421580 created "2016-06-24" @default.
- W2042421580 creator A5006589634 @default.
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- W2042421580 date "2006-05-01" @default.
- W2042421580 modified "2023-10-12" @default.
- W2042421580 title "Bone-related gene profiles in developing calvaria" @default.
- W2042421580 cites W1497791316 @default.
- W2042421580 cites W1650001464 @default.
- W2042421580 cites W1966929992 @default.
- W2042421580 cites W1969381479 @default.
- W2042421580 cites W1969961029 @default.
- W2042421580 cites W1970750249 @default.
- W2042421580 cites W1972209822 @default.
- W2042421580 cites W1974478635 @default.
- W2042421580 cites W1977674617 @default.
- W2042421580 cites W1978622017 @default.
- W2042421580 cites W1979471273 @default.
- W2042421580 cites W1980087281 @default.
- W2042421580 cites W1980145652 @default.
- W2042421580 cites W1980834418 @default.
- W2042421580 cites W1981284961 @default.
- W2042421580 cites W1981340011 @default.
- W2042421580 cites W1981550827 @default.
- W2042421580 cites W1986469118 @default.
- W2042421580 cites W1990196985 @default.
- W2042421580 cites W1994596418 @default.
- W2042421580 cites W1995666993 @default.
- W2042421580 cites W1997453007 @default.
- W2042421580 cites W1997812904 @default.
- W2042421580 cites W2001111734 @default.
- W2042421580 cites W2002279090 @default.
- W2042421580 cites W2002345411 @default.
- W2042421580 cites W2005311368 @default.
- W2042421580 cites W2005810342 @default.
- W2042421580 cites W2006391096 @default.
- W2042421580 cites W2009180025 @default.
- W2042421580 cites W2010118024 @default.
- W2042421580 cites W2011257584 @default.
- W2042421580 cites W2013580179 @default.
- W2042421580 cites W2014659678 @default.
- W2042421580 cites W2020777542 @default.
- W2042421580 cites W2024147232 @default.
- W2042421580 cites W2025682321 @default.
- W2042421580 cites W2030883307 @default.
- W2042421580 cites W2032695925 @default.
- W2042421580 cites W2037561860 @default.
- W2042421580 cites W2039215669 @default.
- W2042421580 cites W2039285533 @default.
- W2042421580 cites W2052673490 @default.
- W2042421580 cites W2053314492 @default.
- W2042421580 cites W2056765403 @default.
- W2042421580 cites W2057806830 @default.
- W2042421580 cites W2059314014 @default.
- W2042421580 cites W2067056588 @default.
- W2042421580 cites W2068208801 @default.
- W2042421580 cites W2070270500 @default.
- W2042421580 cites W2070345664 @default.
- W2042421580 cites W2072148716 @default.
- W2042421580 cites W2075328770 @default.
- W2042421580 cites W2078632150 @default.
- W2042421580 cites W2079533282 @default.
- W2042421580 cites W2080754894 @default.
- W2042421580 cites W2082018889 @default.
- W2042421580 cites W2082408176 @default.
- W2042421580 cites W2082703532 @default.
- W2042421580 cites W2083560073 @default.
- W2042421580 cites W2084875146 @default.
- W2042421580 cites W2092230369 @default.
- W2042421580 cites W2093353711 @default.
- W2042421580 cites W2094522158 @default.
- W2042421580 cites W2097105956 @default.
- W2042421580 cites W2102884982 @default.
- W2042421580 cites W2103012849 @default.
- W2042421580 cites W2103721311 @default.
- W2042421580 cites W2108766777 @default.
- W2042421580 cites W2114162483 @default.
- W2042421580 cites W2114528551 @default.
- W2042421580 cites W2114529565 @default.
- W2042421580 cites W2118390249 @default.
- W2042421580 cites W2122367477 @default.
- W2042421580 cites W2124385965 @default.
- W2042421580 cites W2126482839 @default.
- W2042421580 cites W2128261160 @default.
- W2042421580 cites W2129086150 @default.
- W2042421580 cites W2129904461 @default.
- W2042421580 cites W2133228373 @default.
- W2042421580 cites W2141783706 @default.
- W2042421580 cites W2142928529 @default.
- W2042421580 cites W2150453904 @default.
- W2042421580 cites W2154094043 @default.
- W2042421580 cites W2155343233 @default.