Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042436608> ?p ?o ?g. }
- W2042436608 endingPage "86" @default.
- W2042436608 startingPage "75" @default.
- W2042436608 abstract "Data from various laboratories have indicated associations of various alleles determined by RFLPs within or adjacent to several apolipoprotein genes with abnormalities in plasma lipids and/or premature coronary artery disease (CAD). In order to assess such relationships we have examined allele frequencies of 8 different RFLPs within or adjacent to the apo A-I, C-III and A-IV gene complex on the long arm of chromosome 11 (MspI, 5′ to the apo A-I gene; MspI, within the apo A-1 gene; PstI, 3′ to the apo A-I gene; SstI, 3′ to the apo C-III gene; PvuII, within the apo C-III gene; PvuII, 5′ to the apo C-III gene; XbaI, within the apo A-IV gene; and XbaI, 3′ to the apo A-IV gene) in 202 patients with CAD (50% narrowing of one or more coronary arteries) prior to age 60 and 145 normal controls. None of the allele frequencies of these RFLPs were significantly different in cases as compared to controls. With regard to associations with plasma lipids and apolipoprotein levels, the rare allele determined by the absence of the PstI site was associated with elevated triglyceride levels (P < 0.05) in cases, but not in controls. In contrast, the rare MspI allele 5′ to the apo A-I gene was associated with elevated triglyceride levels (P < 0.05) in controls but not in cases. In both cases and controls, subjects with the uncommon SstI allele had triglyceride levels that were 9 and 38% higher than in those without this allele. These differences were significant (P < 0.05) only in controls. Our data indicate that the rare allele determined by the SstI site within this gene complex deserves further study in order to understand its association with elevated triglycerides in Caucasian populations. However, at the present time all these DNA markers lack sufficient specificity to be clinically useful for CAD risk assessment." @default.
- W2042436608 created "2016-06-24" @default.
- W2042436608 creator A5000776451 @default.
- W2042436608 creator A5017004152 @default.
- W2042436608 creator A5022102417 @default.
- W2042436608 creator A5037218394 @default.
- W2042436608 creator A5037358437 @default.
- W2042436608 creator A5041120194 @default.
- W2042436608 creator A5046213911 @default.
- W2042436608 creator A5048124001 @default.
- W2042436608 creator A5064285461 @default.
- W2042436608 creator A5072893859 @default.
- W2042436608 creator A5073235477 @default.
- W2042436608 creator A5075807528 @default.
- W2042436608 creator A5082213717 @default.
- W2042436608 date "1991-03-01" @default.
- W2042436608 modified "2023-10-18" @default.
- W2042436608 title "Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus Relationships with lipids, apolipoproteins, and premature coronary artery disease" @default.
- W2042436608 cites W1481922934 @default.
- W2042436608 cites W1524287153 @default.
- W2042436608 cites W1608445874 @default.
- W2042436608 cites W1809490782 @default.
- W2042436608 cites W1860487341 @default.
- W2042436608 cites W1965833740 @default.
- W2042436608 cites W1980469014 @default.
- W2042436608 cites W1982154337 @default.
- W2042436608 cites W1986020586 @default.
- W2042436608 cites W1986340013 @default.
- W2042436608 cites W1988386661 @default.
- W2042436608 cites W2001255603 @default.
- W2042436608 cites W2002702884 @default.
- W2042436608 cites W200362752 @default.
- W2042436608 cites W2005500043 @default.
- W2042436608 cites W2012817080 @default.
- W2042436608 cites W2013249935 @default.
- W2042436608 cites W2016212374 @default.
- W2042436608 cites W2016389624 @default.
- W2042436608 cites W2022819900 @default.
- W2042436608 cites W2033022042 @default.
- W2042436608 cites W2036528299 @default.
- W2042436608 cites W2037408127 @default.
- W2042436608 cites W2038143380 @default.
- W2042436608 cites W2039808107 @default.
- W2042436608 cites W2044755530 @default.
- W2042436608 cites W2053912324 @default.
- W2042436608 cites W2062054065 @default.
- W2042436608 cites W2062395148 @default.
- W2042436608 cites W2064028356 @default.
- W2042436608 cites W2069973732 @default.
- W2042436608 cites W2071853748 @default.
- W2042436608 cites W2076962828 @default.
- W2042436608 cites W2081372954 @default.
- W2042436608 cites W2082220604 @default.
- W2042436608 cites W2099351298 @default.
- W2042436608 cites W2104398288 @default.
- W2042436608 cites W2104881623 @default.
- W2042436608 cites W2126389150 @default.
- W2042436608 cites W2143465004 @default.
- W2042436608 cites W2155636004 @default.
- W2042436608 cites W2183999185 @default.
- W2042436608 cites W2313400838 @default.
- W2042436608 cites W2327887667 @default.
- W2042436608 cites W2336194867 @default.
- W2042436608 cites W2341310987 @default.
- W2042436608 cites W2413072380 @default.
- W2042436608 cites W2413728344 @default.
- W2042436608 cites W2413730243 @default.
- W2042436608 cites W2911485752 @default.
- W2042436608 cites W68757838 @default.
- W2042436608 doi "https://doi.org/10.1016/0021-9150(91)90234-t" @default.
- W2042436608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1678604" @default.
- W2042436608 hasPublicationYear "1991" @default.
- W2042436608 type Work @default.
- W2042436608 sameAs 2042436608 @default.
- W2042436608 citedByCount "140" @default.
- W2042436608 countsByYear W20424366082012 @default.
- W2042436608 countsByYear W20424366082013 @default.
- W2042436608 countsByYear W20424366082015 @default.
- W2042436608 countsByYear W20424366082016 @default.
- W2042436608 countsByYear W20424366082018 @default.
- W2042436608 countsByYear W20424366082021 @default.
- W2042436608 countsByYear W20424366082023 @default.
- W2042436608 crossrefType "journal-article" @default.
- W2042436608 hasAuthorship W2042436608A5000776451 @default.
- W2042436608 hasAuthorship W2042436608A5017004152 @default.
- W2042436608 hasAuthorship W2042436608A5022102417 @default.
- W2042436608 hasAuthorship W2042436608A5037218394 @default.
- W2042436608 hasAuthorship W2042436608A5037358437 @default.
- W2042436608 hasAuthorship W2042436608A5041120194 @default.
- W2042436608 hasAuthorship W2042436608A5046213911 @default.
- W2042436608 hasAuthorship W2042436608A5048124001 @default.
- W2042436608 hasAuthorship W2042436608A5064285461 @default.
- W2042436608 hasAuthorship W2042436608A5072893859 @default.
- W2042436608 hasAuthorship W2042436608A5073235477 @default.
- W2042436608 hasAuthorship W2042436608A5075807528 @default.
- W2042436608 hasAuthorship W2042436608A5082213717 @default.
- W2042436608 hasBestOaLocation W20424366081 @default.
- W2042436608 hasConcept C104317684 @default.