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• W2042462385 abstract "The inner ear (vestibular and cochlear) efferent neurons are a group of atypical motor-like hindbrain neurons which innervate inner ear hair cells and their sensory afferents. They are born in the fourth rhombomere, in close association with facial branchial motor neurons, from which they subsequently part through a specific migration route. Here, we demonstrate that the inner ear efferents depend on Phox2b for their differentiation, behaving in that respect like hindbrain visceral and branchial motor neurons. We also show that the vestibular efferent nucleus is no longer present at its usual site in mice inactivated for the bHLH transcription factor Mash 1. The concomitant appearance of an ectopic branchial-like nucleus at the location where both inner ear efferents and facial branchial motor neurons are born suggests that Mash1 is required for the migration of a subpopulation of rhombomere 4-derived efferents." @default.
• W2042462385 created "2016-06-24" @default.
• W2042462385 creator A5020753296 @default.
• W2042462385 creator A5041534461 @default.
• W2042462385 creator A5046022839 @default.
• W2042462385 creator A5046558341 @default.
• W2042462385 date "2003-08-01" @default.
• W2042462385 modified "2023-09-29" @default.
• W2042462385 title "Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus" @default.
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• W2042462385 doi "https://doi.org/10.1016/s0012-1606(03)00213-6" @default.
• W2042462385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12885554" @default.
• W2042462385 hasPublicationYear "2003" @default.
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