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- W2042464282 abstract "AbstractA Copley™ fraction collector and a Disotest™ flow-through system were coupled to provide an automatic discrete sampling flow-through dissolution system for use both in the “open-loop” and “closed-loop” mode. The system was used to investigate the release characteristics of adinazolam in sustained release formulations using a pH 1.2 simulated gastric fluid (without enzymes) dissolution medium (USP XXI). These experimental formulations are designed to provide relatively slow to rapid drug release. The dissolution effluent was analysed off-line by reverse phase HPLC to determine the adinazolam concentration at programmed timed intervals. The differential dissolution profiles produced when the system is used in the “open-loop” configuration are more discriminating in describing the release characteristics of the formulations according to the relative release rates than the “closed-loop” cumulative profiles. Using the characteristic dissolution time parameter from the Weibull function, a better correlation with in vivo bioavailability data was achieved for the data from the system in the “open-loop” mode than when it was used in the “closed-loop” mode. In the “open-loop” mode the Weibull function characteristic dissolution time parameter yielded the best quantitative correlation with a correlation coefficient of 0.92 compared to a value of 0.85 for the “closed-loop” configuration" @default.
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- W2042464282 date "1989-01-01" @default.
- W2042464282 modified "2023-09-26" @default.
- W2042464282 title "A Flow-Through Dissolution Approach to<u>In Vivo/In Vitro</u>Correlation of Adinazolam Release from Sustained Release Formulations" @default.
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- W2042464282 doi "https://doi.org/10.3109/03639048909052526" @default.
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