Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042475669> ?p ?o ?g. }
- W2042475669 endingPage "316" @default.
- W2042475669 startingPage "312" @default.
- W2042475669 abstract "Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays an important role in weight regulation and eating behavior, and poorly balanced diets lead to a decrease in blood BDNF levels. However, studies regarding BDNF blood levels in eating disorders (ED) have yielded inconsistent results. We measured serum concentrations of BDNF and assessed behavior and cognition related to eating in ED patients and control subjects. Forty female drug-free patients [19 with anorexia nervosa (AN), 21 with bulimia nervosa (BN)], who did not meet the diagnostic criteria for depressive disorder, and 24 age-matched normal control subjects were enrolled in the current study. We evaluated eating-related psychopathology and depressive symptoms using the Eating Disorder Inventory-2 (EDI-2), Eating Attitude Test-26 (EAT-26) and the Hamilton Depression Rating Scale (HDRS), and measured serum BDNF levels by an enzyme-linked immunosorbent assay. Compared to normal controls, serum levels of BDNF were significantly reduced in AN, but not in BN. There was a significant positive correlation between serum BDNF levels and BMI in both AN patients (r = .649, p = .003) and BN patients (r = .626, p = .002). However, no correlation between serum BDNF levels and BMI was detected in the controls. Furthermore, there was a significant negative correlation between serum BDNF levels and the oral control subscale scores of EAT in both AN patients (r = − .506, p = .027) and BN patients (r = − .511, p = .018); whereas, no correlation was detected in normal controls. Our study demonstrated that individuals showing more extreme food intake regulation were those with lower serum BDNF levels. This finding is contrary to that in mice where mice with reduced BDNF levels showed aberrant eating behavior. This result suggests that BDNF is no longer functioning appropriately in ED patients, which could be an important factor in the pathophysiological of ED." @default.
- W2042475669 created "2016-06-24" @default.
- W2042475669 creator A5032481392 @default.
- W2042475669 creator A5034640685 @default.
- W2042475669 creator A5040263537 @default.
- W2042475669 creator A5073968894 @default.
- W2042475669 date "2009-03-01" @default.
- W2042475669 modified "2023-09-27" @default.
- W2042475669 title "Low serum BDNF and food intake regulation: A possible new explanation of the pathophysiology of eating disorders" @default.
- W2042475669 cites W1967732556 @default.
- W2042475669 cites W1968213313 @default.
- W2042475669 cites W1972280500 @default.
- W2042475669 cites W1973938481 @default.
- W2042475669 cites W1978282844 @default.
- W2042475669 cites W1979722180 @default.
- W2042475669 cites W1992821811 @default.
- W2042475669 cites W1999128166 @default.
- W2042475669 cites W1999871144 @default.
- W2042475669 cites W2009838896 @default.
- W2042475669 cites W2018490846 @default.
- W2042475669 cites W2027262024 @default.
- W2042475669 cites W2027535421 @default.
- W2042475669 cites W2029184795 @default.
- W2042475669 cites W2029314358 @default.
- W2042475669 cites W2031495339 @default.
- W2042475669 cites W2045355179 @default.
- W2042475669 cites W2052737201 @default.
- W2042475669 cites W2053814015 @default.
- W2042475669 cites W2054985002 @default.
- W2042475669 cites W2066953122 @default.
- W2042475669 cites W2087822915 @default.
- W2042475669 cites W2099804161 @default.
- W2042475669 cites W2114613490 @default.
- W2042475669 cites W2121640875 @default.
- W2042475669 cites W2126175461 @default.
- W2042475669 cites W2133565799 @default.
- W2042475669 cites W2137198040 @default.
- W2042475669 cites W2138263745 @default.
- W2042475669 cites W2159692236 @default.
- W2042475669 cites W2170675493 @default.
- W2042475669 cites W4251391308 @default.
- W2042475669 cites W4300098828 @default.
- W2042475669 doi "https://doi.org/10.1016/j.pnpbp.2008.12.009" @default.
- W2042475669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19152823" @default.
- W2042475669 hasPublicationYear "2009" @default.
- W2042475669 type Work @default.
- W2042475669 sameAs 2042475669 @default.
- W2042475669 citedByCount "59" @default.
- W2042475669 countsByYear W20424756692012 @default.
- W2042475669 countsByYear W20424756692013 @default.
- W2042475669 countsByYear W20424756692014 @default.
- W2042475669 countsByYear W20424756692015 @default.
- W2042475669 countsByYear W20424756692016 @default.
- W2042475669 countsByYear W20424756692017 @default.
- W2042475669 countsByYear W20424756692018 @default.
- W2042475669 countsByYear W20424756692019 @default.
- W2042475669 countsByYear W20424756692020 @default.
- W2042475669 countsByYear W20424756692021 @default.
- W2042475669 countsByYear W20424756692022 @default.
- W2042475669 countsByYear W20424756692023 @default.
- W2042475669 crossrefType "journal-article" @default.
- W2042475669 hasAuthorship W2042475669A5032481392 @default.
- W2042475669 hasAuthorship W2042475669A5034640685 @default.
- W2042475669 hasAuthorship W2042475669A5040263537 @default.
- W2042475669 hasAuthorship W2042475669A5073968894 @default.
- W2042475669 hasConcept C10162356 @default.
- W2042475669 hasConcept C118552586 @default.
- W2042475669 hasConcept C123273963 @default.
- W2042475669 hasConcept C126322002 @default.
- W2042475669 hasConcept C134018914 @default.
- W2042475669 hasConcept C139719470 @default.
- W2042475669 hasConcept C15744967 @default.
- W2042475669 hasConcept C160539049 @default.
- W2042475669 hasConcept C162324750 @default.
- W2042475669 hasConcept C170493617 @default.
- W2042475669 hasConcept C2776394216 @default.
- W2042475669 hasConcept C2776867660 @default.
- W2042475669 hasConcept C2777031586 @default.
- W2042475669 hasConcept C2777556793 @default.
- W2042475669 hasConcept C2778790584 @default.
- W2042475669 hasConcept C71924100 @default.
- W2042475669 hasConceptScore W2042475669C10162356 @default.
- W2042475669 hasConceptScore W2042475669C118552586 @default.
- W2042475669 hasConceptScore W2042475669C123273963 @default.
- W2042475669 hasConceptScore W2042475669C126322002 @default.
- W2042475669 hasConceptScore W2042475669C134018914 @default.
- W2042475669 hasConceptScore W2042475669C139719470 @default.
- W2042475669 hasConceptScore W2042475669C15744967 @default.
- W2042475669 hasConceptScore W2042475669C160539049 @default.
- W2042475669 hasConceptScore W2042475669C162324750 @default.
- W2042475669 hasConceptScore W2042475669C170493617 @default.
- W2042475669 hasConceptScore W2042475669C2776394216 @default.
- W2042475669 hasConceptScore W2042475669C2776867660 @default.
- W2042475669 hasConceptScore W2042475669C2777031586 @default.
- W2042475669 hasConceptScore W2042475669C2777556793 @default.
- W2042475669 hasConceptScore W2042475669C2778790584 @default.
- W2042475669 hasConceptScore W2042475669C71924100 @default.
- W2042475669 hasIssue "2" @default.