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• W2042487634 abstract "AII amacrine cells form a network of electrically coupled interneurons in the mammalian retina and tracer coupling studies suggest that the junctional conductance ( G j ) can be modulated. However, the dynamic range of G j and the functional consequences of varying G j over the dynamic range are unknown. Here we use whole cell recordings from pairs of coupled AII amacrine cells in rat retinal slices to provide direct evidence for physiological modulation of G j , appearing as a time-dependent increase from about 500 pS to a maximum of about 3,000 pS after 30–90 min of recording. The increase occurred in recordings with low- but not high-resistance pipettes, suggesting that it was related to intracellular washout and perturbation of a modulatory system. Computer simulations of a network of electrically coupled cells verified that our recordings were able to detect and quantify changes in G j over a large range. Dynamic-clamp electrophysiology, with insertion of electrical synapses between AII amacrine cells, allowed us to finely and reversibly control G j within the same range observed for physiologically coupled cells and to examine the quantitative relationship between G j and steady-state coupling coefficient, synchronization of subthreshold membrane potential fluctuations, synchronization and transmission of action potentials, and low-pass filter characteristics. The range of G j values over which signal transmission was modulated depended strongly on the specific functional parameter examined, with the largest range observed for action potential transmission and synchronization, suggesting that the full range of G j values observed during spontaneous run-up of coupling could represent a physiologically relevant dynamic range." @default.
• W2042487634 created "2016-06-24" @default.
• W2042487634 creator A5049472930 @default.
• W2042487634 creator A5053260856 @default.
• W2042487634 creator A5058079696 @default.
• W2042487634 date "2008-12-01" @default.
• W2042487634 modified "2023-09-23" @default.
• W2042487634 title "Electrical Synapses Between AII Amacrine Cells: Dynamic Range and Functional Consequences of Variation in Junctional Conductance" @default.
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• W2042487634 doi "https://doi.org/10.1152/jn.90957.2008" @default.
• W2042487634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18922943" @default.
• W2042487634 hasPublicationYear "2008" @default.
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