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- W2042491007 abstract "We examined the hypothesis that recording multiple elastic pressure–volume (Pel/V) curves and calculating alveolar derecruitment (VDER) induced by decreasing positive end-expiratory pressure (PEEP) may allow determination of alveolar closing pressures, thus helping to select the optimal PEEP level. VDER measured in 16 patients with acute lung injury (ALI) was compared with the lower inflection point (LIP) and oxygenation changes. A modified automated method was used to record multiple Pel/V curves at low constant flow. PEEP was decreased in 5-cm H2O steps, from 20 or 15 cm H2O to 0 cm H2O (ZEEP). VDER was the volume loss between the curves recorded from PEEP and from ZEEP at the same Pel. Derecruitment occurred at each PEEP decrement, being spread almost uniformly over the 20/15 to 0 cm H2O range. VDER was not correlated with LIP. VDER changes correlated with PaO2 /Fi O2 changes (rho = 0.6, p = 0.02). Linear compliance at ZEEP was correlated to VDER at PEEP 15 cm H2O (rho = 0.9, p = 0.001), suggesting tha..." @default.
- W2042491007 created "2016-06-24" @default.
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- W2042491007 date "2002-10-15" @default.
- W2042491007 modified "2023-09-26" @default.
- W2042491007 title "Alveolar derecruitment at decremental positive end-expiratory pressure levels in acute lung injury" @default.
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- W2042491007 doi "https://doi.org/10.1164/ajrccm.166.8.257" @default.
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