FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042520753> ?p ?o ?g. }

• W2042520753 endingPage "2752" @default.
• W2042520753 startingPage "2744" @default.
• W2042520753 abstract "The BCR/ABL oncogene is responsible for the phenotype of Philadelphia chromosome-positive (Ph+) leukemia. BCR/ABL exhibits an aberrant ABL-tyrosine kinase activity. The treatment of advanced Ph+ leukemia with selective ABL-kinase inhibitors such as Imatinib, Nilotinib and Dasatinib is initially effective but rapidly followed by resistance mainly because of specific mutations in BCR/ABL. Tetramerization of ABL through the N-terminal coiled-coil region (CC) of BCR is essential for the ABL-kinase activation. Targeting the CC-domain forces BCR/ABL into a monomeric conformation reduces its kinase activity and increases the sensitivity for Imatinib. We show that (i) targeting the tetramerization by a peptide representing the Helix-2 of the CC efficiently reduced the autophosphorylation of both unmutated and mutated BCR/ABL; (ii) Helix-2 inhibited the transformation potential of BCR/ABL independently of the presence of mutations; and (iii) Helix-2 efficiently cooperated with Imatinib as revealed by their effects on the transformation potential and the factor-independence related to BCR/ABL with the exception of mutant T315I. These findings support earlier observations that BCR/ABL harboring the T315I mutation have a transformation potential that is at least partially independent of its kinase activity. These data provide evidence that the inhibition of tetramerization inhibits BCR/ABL-mediated transformation and can contribute to overcome Imatinib-resistance. © 2008 Wiley-Liss, Inc." @default.
• W2042520753 created "2016-06-24" @default.
• W2042520753 creator A5005531458 @default.
• W2042520753 creator A5022942761 @default.
• W2042520753 creator A5025576419 @default.
• W2042520753 creator A5043761513 @default.
• W2042520753 creator A5049626418 @default.
• W2042520753 creator A5087126280 @default.
• W2042520753 creator A5088020230 @default.
• W2042520753 date "2008-01-01" @default.
• W2042520753 modified "2023-10-06" @default.
• W2042520753 title "Targeting of the N-terminal coiled coil oligomerization interface by a helix-2 peptide inhibits unmutated and imatinib-resistant BCR/ABL" @default.
• W2042520753 cites W120676909 @default.
• W2042520753 cites W1572020409 @default.
• W2042520753 cites W1607666343 @default.
• W2042520753 cites W1857306005 @default.
• W2042520753 cites W2006518962 @default.
• W2042520753 cites W2009785675 @default.
• W2042520753 cites W2012745815 @default.
• W2042520753 cites W2014249275 @default.
• W2042520753 cites W2016086822 @default.
• W2042520753 cites W2016656445 @default.
• W2042520753 cites W2033061315 @default.
• W2042520753 cites W2040396943 @default.
• W2042520753 cites W2057147161 @default.
• W2042520753 cites W2059059532 @default.
• W2042520753 cites W2087985781 @default.
• W2042520753 cites W2097946794 @default.
• W2042520753 cites W2119629171 @default.
• W2042520753 cites W2125135039 @default.
• W2042520753 cites W2131174104 @default.
• W2042520753 cites W2131476854 @default.
• W2042520753 cites W2131501125 @default.
• W2042520753 cites W2150148922 @default.
• W2042520753 cites W2155995515 @default.
• W2042520753 cites W2157693529 @default.
• W2042520753 cites W2231637212 @default.
• W2042520753 cites W2263837564 @default.
• W2042520753 cites W2314938037 @default.
• W2042520753 cites W2410546905 @default.
• W2042520753 doi "https://doi.org/10.1002/ijc.23467" @default.
• W2042520753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18366061" @default.
• W2042520753 hasPublicationYear "2008" @default.
• W2042520753 type Work @default.
• W2042520753 sameAs 2042520753 @default.
• W2042520753 citedByCount "39" @default.
• W2042520753 countsByYear W20425207532012 @default.
• W2042520753 countsByYear W20425207532013 @default.
• W2042520753 countsByYear W20425207532014 @default.
• W2042520753 countsByYear W20425207532015 @default.
• W2042520753 countsByYear W20425207532016 @default.
• W2042520753 countsByYear W20425207532017 @default.
• W2042520753 countsByYear W20425207532018 @default.
• W2042520753 countsByYear W20425207532020 @default.
• W2042520753 countsByYear W20425207532021 @default.
• W2042520753 countsByYear W20425207532022 @default.
• W2042520753 crossrefType "journal-article" @default.
• W2042520753 hasAuthorship W2042520753A5005531458 @default.
• W2042520753 hasAuthorship W2042520753A5022942761 @default.
• W2042520753 hasAuthorship W2042520753A5025576419 @default.
• W2042520753 hasAuthorship W2042520753A5043761513 @default.
• W2042520753 hasAuthorship W2042520753A5049626418 @default.
• W2042520753 hasAuthorship W2042520753A5087126280 @default.
• W2042520753 hasAuthorship W2042520753A5088020230 @default.
• W2042520753 hasBestOaLocation W20425207531 @default.
• W2042520753 hasConcept C104317684 @default.
• W2042520753 hasConcept C11960822 @default.
• W2042520753 hasConcept C125418893 @default.
• W2042520753 hasConcept C138626823 @default.
• W2042520753 hasConcept C143065580 @default.
• W2042520753 hasConcept C150109051 @default.
• W2042520753 hasConcept C170493617 @default.
• W2042520753 hasConcept C184235292 @default.
• W2042520753 hasConcept C185592680 @default.
• W2042520753 hasConcept C2777413986 @default.
• W2042520753 hasConcept C2777583451 @default.
• W2042520753 hasConcept C2778729363 @default.
• W2042520753 hasConcept C2778904597 @default.
• W2042520753 hasConcept C2779536868 @default.
• W2042520753 hasConcept C3019892230 @default.
• W2042520753 hasConcept C32619005 @default.
• W2042520753 hasConcept C42362537 @default.
• W2042520753 hasConcept C43907098 @default.
• W2042520753 hasConcept C502942594 @default.
• W2042520753 hasConcept C55493867 @default.
• W2042520753 hasConcept C62478195 @default.
• W2042520753 hasConcept C86803240 @default.
• W2042520753 hasConcept C95444343 @default.
• W2042520753 hasConcept C97029542 @default.
• W2042520753 hasConceptScore W2042520753C104317684 @default.
• W2042520753 hasConceptScore W2042520753C11960822 @default.
• W2042520753 hasConceptScore W2042520753C125418893 @default.
• W2042520753 hasConceptScore W2042520753C138626823 @default.
• W2042520753 hasConceptScore W2042520753C143065580 @default.
• W2042520753 hasConceptScore W2042520753C150109051 @default.
• W2042520753 hasConceptScore W2042520753C170493617 @default.
• W2042520753 hasConceptScore W2042520753C184235292 @default.
• W2042520753 hasConceptScore W2042520753C185592680 @default.

• next