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• W2042526236 abstract "Purpose – We reviewed the impact of planned discontinuation of antiepileptic drugs (AEDs) in seizure-free patients on seizure recurrence and the seizure outcome of reinstituted treatment. Methods – A literature review was performed yielding 14 clinical observations of seizure recurrence after discontinuation and its treatment outcome. Results – Seizure recurrence rate after AED discontinuation ranged between 12 and 66% (mean 34%, 95%CI: 27–43) in the 13 reviewed studies (no data in one study). Reinstitution of AEDs after recurrence was efficacious between 64–91% (mean of 14 studies, 80%, 95%CI: 75–85%) at follow-up. Mean follow-up ranged from 1–9 years. Seizure outcome of resumed treatment was not different for series in children and adolescents (84%, mean of 4 studies, 95%CI: 75–93) or in adults only (80%, mean of 9 studies, 95%CI: 74–86). Although seizure control was regained within approximately one year in half of the cases becoming seizure free, it took some patients as many as 5–12 years. In addition, in 19% (mean of 14 studies, 95%CI: 15–24%), resuming medication did not control the epilepsy as before, and chronic drug-resistant epilepsy with many seizures over as many as five years was seen in up to 23% of patients with a recurrence. Factors associated with poor treatment outcome of treating recurrences were symptomatic etiology, partial epilepsy and cognitive deficits. Conclusions – These serious and substantial risks weigh against discontinuation of AEDs in seizure-free patients, except perhaps for selected patients with idiopathic epilepsy syndromes of childhood or patients with rare seizures." @default.
• W2042526236 created "2016-06-24" @default.
• W2042526236 creator A5010235451 @default.
• W2042526236 creator A5048652296 @default.
• W2042526236 date "2005-04-07" @default.
• W2042526236 modified "2023-09-25" @default.
• W2042526236 title "Uncontrolled epilepsy following discontinuation of antiepileptic drugs in seizure-free patients: a review of current clinical experience" @default.
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• W2042526236 doi "https://doi.org/10.1111/j.1600-0404.2005.00408.x" @default.
• W2042526236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15819708" @default.
• W2042526236 hasPublicationYear "2005" @default.
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