FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042528503> ?p ?o ?g. }

• W2042528503 endingPage "337" @default.
• W2042528503 startingPage "328" @default.
• W2042528503 abstract "InhA is an enoyl-ACP reductase of Mycobacterium tuberculosis implicated in the biosynthesis of mycolic acids, essential constituents of the mycobacterial cell wall. To date, this enzyme is considered as a promising target for the discovery of novel antitubercular drugs. In this work, we describe the first crystal structure of the apo form of the wild-type InhA at 1.80 Å resolution as well as the crystal structure of InhA in complex with the synthetic metabolite of the antitubercular drug isoniazid refined to 1.40 Å. This metabolite, synthesized in the absence of InhA, is able to displace and replace the cofactor NADH in the enzyme active site. This work provides a unique opportunity to enlighten the structural adaptation of apo-InhA to the binding of the NADH cofactor or of the isoniazid adduct. In addition, a differential scanning fluorimetry study of InhA, in the apo-form as well as in the presence of NAD+, NADH and INH-NADH was performed showing that binding of the INH-NADH adduct had a strong stabilizing effect." @default.
• W2042528503 created "2016-06-24" @default.
• W2042528503 creator A5006971668 @default.
• W2042528503 creator A5012367794 @default.
• W2042528503 creator A5016842505 @default.
• W2042528503 creator A5031923797 @default.
• W2042528503 creator A5037362727 @default.
• W2042528503 creator A5050447691 @default.
• W2042528503 creator A5060247122 @default.
• W2042528503 creator A5066210282 @default.
• W2042528503 creator A5069188437 @default.
• W2042528503 creator A5076353891 @default.
• W2042528503 date "2015-06-01" @default.
• W2042528503 modified "2023-10-16" @default.
• W2042528503 title "Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach" @default.
• W2042528503 cites W1849836964 @default.
• W2042528503 cites W1971174290 @default.
• W2042528503 cites W1973725396 @default.
• W2042528503 cites W1978582732 @default.
• W2042528503 cites W1982542062 @default.
• W2042528503 cites W1983818377 @default.
• W2042528503 cites W1988922143 @default.
• W2042528503 cites W1991640599 @default.
• W2042528503 cites W1995337432 @default.
• W2042528503 cites W1996130189 @default.
• W2042528503 cites W2001414564 @default.
• W2042528503 cites W2010302366 @default.
• W2042528503 cites W2020948468 @default.
• W2042528503 cites W2027340405 @default.
• W2042528503 cites W2027887879 @default.
• W2042528503 cites W2036391785 @default.
• W2042528503 cites W2046109239 @default.
• W2042528503 cites W2058895505 @default.
• W2042528503 cites W2064746154 @default.
• W2042528503 cites W2073691834 @default.
• W2042528503 cites W2075000963 @default.
• W2042528503 cites W2092026968 @default.
• W2042528503 cites W2093712250 @default.
• W2042528503 cites W2095576080 @default.
• W2042528503 cites W2106290432 @default.
• W2042528503 cites W2107851387 @default.
• W2042528503 cites W2108628979 @default.
• W2042528503 cites W2108921801 @default.
• W2042528503 cites W2109565282 @default.
• W2042528503 cites W2112708983 @default.
• W2042528503 cites W2113461878 @default.
• W2042528503 cites W2117610468 @default.
• W2042528503 cites W2128034051 @default.
• W2042528503 cites W2134334215 @default.
• W2042528503 cites W2139106269 @default.
• W2042528503 cites W2142907906 @default.
• W2042528503 cites W2143660875 @default.
• W2042528503 cites W2144081223 @default.
• W2042528503 cites W2159211495 @default.
• W2042528503 cites W2164766801 @default.
• W2042528503 cites W2180229411 @default.
• W2042528503 cites W4248872320 @default.
• W2042528503 doi "https://doi.org/10.1016/j.jsb.2015.04.008" @default.
• W2042528503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25891098" @default.
• W2042528503 hasPublicationYear "2015" @default.
• W2042528503 type Work @default.
• W2042528503 sameAs 2042528503 @default.
• W2042528503 citedByCount "25" @default.
• W2042528503 countsByYear W20425285032016 @default.
• W2042528503 countsByYear W20425285032017 @default.
• W2042528503 countsByYear W20425285032018 @default.
• W2042528503 countsByYear W20425285032019 @default.
• W2042528503 countsByYear W20425285032020 @default.
• W2042528503 countsByYear W20425285032021 @default.
• W2042528503 countsByYear W20425285032022 @default.
• W2042528503 countsByYear W20425285032023 @default.
• W2042528503 crossrefType "journal-article" @default.
• W2042528503 hasAuthorship W2042528503A5006971668 @default.
• W2042528503 hasAuthorship W2042528503A5012367794 @default.
• W2042528503 hasAuthorship W2042528503A5016842505 @default.
• W2042528503 hasAuthorship W2042528503A5031923797 @default.
• W2042528503 hasAuthorship W2042528503A5037362727 @default.
• W2042528503 hasAuthorship W2042528503A5050447691 @default.
• W2042528503 hasAuthorship W2042528503A5060247122 @default.
• W2042528503 hasAuthorship W2042528503A5066210282 @default.
• W2042528503 hasAuthorship W2042528503A5069188437 @default.
• W2042528503 hasAuthorship W2042528503A5076353891 @default.
• W2042528503 hasBestOaLocation W20425285032 @default.
• W2042528503 hasConcept C134651460 @default.
• W2042528503 hasConcept C142724271 @default.
• W2042528503 hasConcept C181199279 @default.
• W2042528503 hasConcept C185592680 @default.
• W2042528503 hasConcept C197957613 @default.
• W2042528503 hasConcept C2776967927 @default.
• W2042528503 hasConcept C2777477808 @default.
• W2042528503 hasConcept C2777975735 @default.
• W2042528503 hasConcept C2780687663 @default.
• W2042528503 hasConcept C2781069245 @default.
• W2042528503 hasConcept C2910800646 @default.
• W2042528503 hasConcept C55493867 @default.
• W2042528503 hasConcept C71240020 @default.
• W2042528503 hasConcept C71924100 @default.
• W2042528503 hasConcept C75520062 @default.

• next