FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042529843> ?p ?o ?g. }

• W2042529843 endingPage "383" @default.
• W2042529843 startingPage "376" @default.
• W2042529843 abstract "Extracellular matrix dynamics, crucial for tissue remodelling, are highly regulated by a cascade of matrix metalloproteinases (MMPs) during inflammation and wound healing processes in inflammatory bowel disease (IBD). Contrary to expectations, there are limited reports to date that MMP inhibitors have some beneficial therapeutic effects in experimental colitis models. Furthermore, clinical trials of MMP inhibitors against certain tumours have failed to show any therapeutic benefit. One major reason for this lack of success may be the apparent uncertainty about the precise spectrum of inhibitory activity required. Since tumour necrosis factor alpha (TNFα), a key mediator in colonic inflammation, promotes MMP production in a dose-dependent manner, the therapeutic success of anti-TNFα agents against IBD motivated us to re-evaluate the therapeutic potential of MMP inhibition. First, using a quantitative polymerase chain reaction (PCR), western blotting, and zymography, we determined which MMPs were relevant to experimental colitis induced in mice by dextran sulphate sodium. Next, we examined a distinct role for MAPK and NFκB signalling pathways in the regulation of the expression of these MMP genes. Finally, we examined whether transcriptional regulation of these MMPs, either indirectly using inhibitors of MAPK and/or NFκB signalling pathways or directly using siRNA directed against these MMPs, contributes to the prevention of colitis. Changes in the expression level of colonic MMP-3 and MMP-10 preceded the clinical course of colitis. Colitis improved in mice that received these signal inhibitors, together with suppression of MMP expression. Moreover, siRNA that targeted MMP-3 and MMP-10 effectively reduced both the transcription of these MMPs and the severity of colitis. We conclude that MMP-3 and MMP-10 play a causal role in excess tissue destruction in colitis. Specific inhibition of these MMPs should provide novel therapeutics against IBD. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
• W2042529843 created "2016-06-24" @default.
• W2042529843 creator A5028932589 @default.
• W2042529843 creator A5029539793 @default.
• W2042529843 creator A5043433351 @default.
• W2042529843 creator A5047971248 @default.
• W2042529843 creator A5052743109 @default.
• W2042529843 creator A5083651359 @default.
• W2042529843 creator A5087050645 @default.
• W2042529843 date "2006-01-01" @default.
• W2042529843 modified "2023-10-11" @default.
• W2042529843 title "Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium" @default.
• W2042529843 cites W1611419331 @default.
• W2042529843 cites W1670317346 @default.
• W2042529843 cites W1754450379 @default.
• W2042529843 cites W1886431664 @default.
• W2042529843 cites W1894541755 @default.
• W2042529843 cites W1905017519 @default.
• W2042529843 cites W1921554018 @default.
• W2042529843 cites W1951491012 @default.
• W2042529843 cites W1978565185 @default.
• W2042529843 cites W1985056073 @default.
• W2042529843 cites W1994733930 @default.
• W2042529843 cites W1996163490 @default.
• W2042529843 cites W2011302251 @default.
• W2042529843 cites W2012547585 @default.
• W2042529843 cites W2016971493 @default.
• W2042529843 cites W2020923434 @default.
• W2042529843 cites W2023780438 @default.
• W2042529843 cites W2032000852 @default.
• W2042529843 cites W2034011718 @default.
• W2042529843 cites W2047207866 @default.
• W2042529843 cites W2093560642 @default.
• W2042529843 cites W2107235611 @default.
• W2042529843 cites W2114466604 @default.
• W2042529843 cites W2120213130 @default.
• W2042529843 cites W2128049766 @default.
• W2042529843 cites W2146007432 @default.
• W2042529843 cites W2153709000 @default.
• W2042529843 cites W2153734123 @default.
• W2042529843 cites W2155414925 @default.
• W2042529843 cites W2158579616 @default.
• W2042529843 cites W2163634416 @default.
• W2042529843 cites W2171297959 @default.
• W2042529843 cites W4250908540 @default.
• W2042529843 doi "https://doi.org/10.1002/path.1978" @default.
• W2042529843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16552705" @default.
• W2042529843 hasPublicationYear "2006" @default.
• W2042529843 type Work @default.
• W2042529843 sameAs 2042529843 @default.
• W2042529843 citedByCount "39" @default.
• W2042529843 countsByYear W20425298432012 @default.
• W2042529843 countsByYear W20425298432013 @default.
• W2042529843 countsByYear W20425298432014 @default.
• W2042529843 countsByYear W20425298432015 @default.
• W2042529843 countsByYear W20425298432016 @default.
• W2042529843 countsByYear W20425298432019 @default.
• W2042529843 countsByYear W20425298432020 @default.
• W2042529843 countsByYear W20425298432023 @default.
• W2042529843 crossrefType "journal-article" @default.
• W2042529843 hasAuthorship W2042529843A5028932589 @default.
• W2042529843 hasAuthorship W2042529843A5029539793 @default.
• W2042529843 hasAuthorship W2042529843A5043433351 @default.
• W2042529843 hasAuthorship W2042529843A5047971248 @default.
• W2042529843 hasAuthorship W2042529843A5052743109 @default.
• W2042529843 hasAuthorship W2042529843A5083651359 @default.
• W2042529843 hasAuthorship W2042529843A5087050645 @default.
• W2042529843 hasConcept C109523444 @default.
• W2042529843 hasConcept C126322002 @default.
• W2042529843 hasConcept C177430391 @default.
• W2042529843 hasConcept C17991360 @default.
• W2042529843 hasConcept C185592680 @default.
• W2042529843 hasConcept C189165786 @default.
• W2042529843 hasConcept C203014093 @default.
• W2042529843 hasConcept C2107291 @default.
• W2042529843 hasConcept C2775862500 @default.
• W2042529843 hasConcept C2775958869 @default.
• W2042529843 hasConcept C2776914184 @default.
• W2042529843 hasConcept C2778260677 @default.
• W2042529843 hasConcept C2779134260 @default.
• W2042529843 hasConcept C502942594 @default.
• W2042529843 hasConcept C57074206 @default.
• W2042529843 hasConcept C62478195 @default.
• W2042529843 hasConcept C71924100 @default.
• W2042529843 hasConcept C86803240 @default.
• W2042529843 hasConcept C95444343 @default.
• W2042529843 hasConcept C98274493 @default.
• W2042529843 hasConceptScore W2042529843C109523444 @default.
• W2042529843 hasConceptScore W2042529843C126322002 @default.
• W2042529843 hasConceptScore W2042529843C177430391 @default.
• W2042529843 hasConceptScore W2042529843C17991360 @default.
• W2042529843 hasConceptScore W2042529843C185592680 @default.
• W2042529843 hasConceptScore W2042529843C189165786 @default.
• W2042529843 hasConceptScore W2042529843C203014093 @default.
• W2042529843 hasConceptScore W2042529843C2107291 @default.
• W2042529843 hasConceptScore W2042529843C2775862500 @default.
• W2042529843 hasConceptScore W2042529843C2775958869 @default.
• W2042529843 hasConceptScore W2042529843C2776914184 @default.

• next