Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042531378> ?p ?o ?g. }
- W2042531378 endingPage "381" @default.
- W2042531378 startingPage "376" @default.
- W2042531378 abstract "There is increased interest in the effects of secretory products from aged cells on promoting both benign and malignant cell growth. We identified a human fibroblast line, AG04382, from an aged donor that naturally demonstrated senescence-associated features and whose conditioned media significantly induced proliferation of benign prostatic hyperplasia (BPH1) cells. Candidate cytokines mediating this effect were identified with protein arrays and validated by ELISA. We found that the AG04382 fibroblast line secreted high levels of CXCL5, CCL5, and CCL2, but relative to the other lines, its conditioned media was unique in its increased expression of CCL5. Blocking studies using specific antibodies against CXCL5, CCL5, and CCL2 in the conditioned media of AG04382 showed that only CCL5 contributed significantly to BPH1 proliferation. Stimulation of BPH1 cells with rhuCCL5 resulted in increased proliferation and migration, as well as significant changes in the expression of genes that influence angiogenesis. These data suggest that CCL5 is a candidate chemokine secreted by aged cells that promotes prostate growth and regulates angiogenesis. J. Cell. Physiol. 220: 376–381, 2009. © 2009 Wiley-Liss, Inc." @default.
- W2042531378 created "2016-06-24" @default.
- W2042531378 creator A5007982307 @default.
- W2042531378 creator A5028647192 @default.
- W2042531378 creator A5033074533 @default.
- W2042531378 creator A5046611314 @default.
- W2042531378 date "2009-08-01" @default.
- W2042531378 modified "2023-09-26" @default.
- W2042531378 title "CCL5 secreted by senescent aged fibroblasts induces proliferation of prostate epithelial cells and expression of genes that modulate angiogenesis" @default.
- W2042531378 cites W1561228697 @default.
- W2042531378 cites W1581259003 @default.
- W2042531378 cites W1593300855 @default.
- W2042531378 cites W1965179151 @default.
- W2042531378 cites W1974557172 @default.
- W2042531378 cites W1975069346 @default.
- W2042531378 cites W1975555969 @default.
- W2042531378 cites W1978401724 @default.
- W2042531378 cites W1981147501 @default.
- W2042531378 cites W1982673084 @default.
- W2042531378 cites W2000556101 @default.
- W2042531378 cites W2006961352 @default.
- W2042531378 cites W2009270104 @default.
- W2042531378 cites W2010146889 @default.
- W2042531378 cites W2024209230 @default.
- W2042531378 cites W2031951436 @default.
- W2042531378 cites W2034320146 @default.
- W2042531378 cites W2037023229 @default.
- W2042531378 cites W2050344387 @default.
- W2042531378 cites W2052413295 @default.
- W2042531378 cites W2053831799 @default.
- W2042531378 cites W2060979010 @default.
- W2042531378 cites W2067863474 @default.
- W2042531378 cites W2070338369 @default.
- W2042531378 cites W2070885297 @default.
- W2042531378 cites W2075600855 @default.
- W2042531378 cites W2077665257 @default.
- W2042531378 cites W2088188305 @default.
- W2042531378 cites W2090575954 @default.
- W2042531378 cites W2090788158 @default.
- W2042531378 cites W2091369486 @default.
- W2042531378 cites W2091762807 @default.
- W2042531378 cites W2092243672 @default.
- W2042531378 cites W2097125354 @default.
- W2042531378 cites W2098009765 @default.
- W2042531378 cites W2100065850 @default.
- W2042531378 cites W2104908670 @default.
- W2042531378 cites W2112334521 @default.
- W2042531378 cites W2117345526 @default.
- W2042531378 cites W2117869125 @default.
- W2042531378 cites W2119930698 @default.
- W2042531378 cites W2123684807 @default.
- W2042531378 cites W2135829603 @default.
- W2042531378 cites W2138788396 @default.
- W2042531378 cites W2141720111 @default.
- W2042531378 cites W2142480001 @default.
- W2042531378 cites W2147820545 @default.
- W2042531378 cites W2148120568 @default.
- W2042531378 cites W2158831697 @default.
- W2042531378 cites W2163303508 @default.
- W2042531378 cites W2163525357 @default.
- W2042531378 cites W2169612578 @default.
- W2042531378 cites W2169664148 @default.
- W2042531378 doi "https://doi.org/10.1002/jcp.21776" @default.
- W2042531378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2846281" @default.
- W2042531378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19360811" @default.
- W2042531378 hasPublicationYear "2009" @default.
- W2042531378 type Work @default.
- W2042531378 sameAs 2042531378 @default.
- W2042531378 citedByCount "48" @default.
- W2042531378 countsByYear W20425313782012 @default.
- W2042531378 countsByYear W20425313782013 @default.
- W2042531378 countsByYear W20425313782014 @default.
- W2042531378 countsByYear W20425313782015 @default.
- W2042531378 countsByYear W20425313782017 @default.
- W2042531378 countsByYear W20425313782018 @default.
- W2042531378 countsByYear W20425313782019 @default.
- W2042531378 countsByYear W20425313782020 @default.
- W2042531378 countsByYear W20425313782021 @default.
- W2042531378 countsByYear W20425313782022 @default.
- W2042531378 countsByYear W20425313782023 @default.
- W2042531378 crossrefType "journal-article" @default.
- W2042531378 hasAuthorship W2042531378A5007982307 @default.
- W2042531378 hasAuthorship W2042531378A5028647192 @default.
- W2042531378 hasAuthorship W2042531378A5033074533 @default.
- W2042531378 hasAuthorship W2042531378A5046611314 @default.
- W2042531378 hasBestOaLocation W20425313782 @default.
- W2042531378 hasConcept C101666144 @default.
- W2042531378 hasConcept C116484652 @default.
- W2042531378 hasConcept C13373296 @default.
- W2042531378 hasConcept C203014093 @default.
- W2042531378 hasConcept C2776090121 @default.
- W2042531378 hasConcept C2776914184 @default.
- W2042531378 hasConcept C2778690821 @default.
- W2042531378 hasConcept C2780394083 @default.
- W2042531378 hasConcept C502942594 @default.
- W2042531378 hasConcept C522857546 @default.
- W2042531378 hasConcept C54355233 @default.
- W2042531378 hasConcept C62112901 @default.