FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042536320> ?p ?o ?g. }

• W2042536320 endingPage "115" @default.
• W2042536320 startingPage "108" @default.
• W2042536320 abstract "The effect of a β-adrenergic agonist (isoproterenol) on the tyrosine kinase activity of the insulin receptor was studied in intact adipocytes. Isoproterenol treatment rapidly (5 min) inhibited the insulin-induced autophosphorylation of the insulin receptor on tyrosine residues in intact adipocytes. The effect of insulin on the phosphorylation of cellular proteins on tyrosine residues was also inhibited by isoproterenol. In order to understand the mechanism responsible for this inhibition, two-dimensional phosphopeptide mapping of the insulin receptor was performed. The pattern of phosphorylation of the insulin receptor in freshly isolated adipocytes showed marked differences from that previously observed in cultured cells overexpressing insulin receptors. These differences include a larger proportion of receptors being phosphorylated on the three tyrosines from the kinase domain and no apparent phosphorylation of the two tyrosines close to the C-terminus after insulin stimulation. Isoproterenol markedly inhibited the effect of insulin on the phosphorylation of the three tyrosines from the kinase domain. However, this inhibition was not associated with an increase in the phosphorylation of serine/threonine peptides. Thus, this direct analysis of insulin receptor phosphorylation sites in intact adipocytes does no support the idea that β-adrenegic agents inhibit the tyrosine kinase activity of the receptor through a serine/threonine phosphorylation-dependent mechanism." @default.
• W2042536320 created "2016-06-24" @default.
• W2042536320 creator A5050955692 @default.
• W2042536320 creator A5056942358 @default.
• W2042536320 creator A5077044814 @default.
• W2042536320 date "1995-11-01" @default.
• W2042536320 modified "2023-10-18" @default.
• W2042536320 title "Isoproterenol Inhibits Insulin-Stimulated Tyrosine Phosphorylation of the Insulin Receptor Without Increasing its Serine/Threonine Phosphorylation" @default.
• W2042536320 cites W11465583 @default.
• W2042536320 cites W139486684 @default.
• W2042536320 cites W144116101 @default.
• W2042536320 cites W148034935 @default.
• W2042536320 cites W1504728510 @default.
• W2042536320 cites W1509980140 @default.
• W2042536320 cites W1532404678 @default.
• W2042536320 cites W1539281575 @default.
• W2042536320 cites W1548061249 @default.
• W2042536320 cites W1550332341 @default.
• W2042536320 cites W1570629413 @default.
• W2042536320 cites W1572009433 @default.
• W2042536320 cites W1588222095 @default.
• W2042536320 cites W1592486826 @default.
• W2042536320 cites W1596955093 @default.
• W2042536320 cites W1602851982 @default.
• W2042536320 cites W1608611896 @default.
• W2042536320 cites W1624505911 @default.
• W2042536320 cites W1676815435 @default.
• W2042536320 cites W1776247902 @default.
• W2042536320 cites W1831457297 @default.
• W2042536320 cites W1925991305 @default.
• W2042536320 cites W1972745058 @default.
• W2042536320 cites W1977941956 @default.
• W2042536320 cites W2005197874 @default.
• W2042536320 cites W2017297720 @default.
• W2042536320 cites W2030156849 @default.
• W2042536320 cites W2033093772 @default.
• W2042536320 cites W2033429522 @default.
• W2042536320 cites W2038026039 @default.
• W2042536320 cites W2040660469 @default.
• W2042536320 cites W2041216506 @default.
• W2042536320 cites W2050560415 @default.
• W2042536320 cites W2051844431 @default.
• W2042536320 cites W2055852252 @default.
• W2042536320 cites W2064801081 @default.
• W2042536320 cites W2076611219 @default.
• W2042536320 cites W2079679502 @default.
• W2042536320 cites W2083106972 @default.
• W2042536320 cites W2104018189 @default.
• W2042536320 cites W2104918602 @default.
• W2042536320 cites W2116723161 @default.
• W2042536320 cites W2123272485 @default.
• W2042536320 cites W2132647577 @default.
• W2042536320 cites W2141448939 @default.
• W2042536320 cites W2143873575 @default.
• W2042536320 cites W2225020375 @default.
• W2042536320 cites W2237210219 @default.
• W2042536320 cites W2340564670 @default.
• W2042536320 cites W2398679444 @default.
• W2042536320 cites W2400372516 @default.
• W2042536320 cites W4239622495 @default.
• W2042536320 cites W4246749417 @default.
• W2042536320 cites W4256296885 @default.
• W2042536320 cites W48874134 @default.
• W2042536320 cites W2009164764 @default.
• W2042536320 doi "https://doi.org/10.1111/j.1432-1033.1995.108_c.x" @default.
• W2042536320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8529629" @default.
• W2042536320 hasPublicationYear "1995" @default.
• W2042536320 type Work @default.
• W2042536320 sameAs 2042536320 @default.
• W2042536320 citedByCount "42" @default.
• W2042536320 countsByYear W20425363202012 @default.
• W2042536320 countsByYear W20425363202013 @default.
• W2042536320 countsByYear W20425363202014 @default.
• W2042536320 countsByYear W20425363202015 @default.
• W2042536320 countsByYear W20425363202016 @default.
• W2042536320 countsByYear W20425363202017 @default.
• W2042536320 countsByYear W20425363202018 @default.
• W2042536320 countsByYear W20425363202020 @default.
• W2042536320 countsByYear W20425363202021 @default.
• W2042536320 crossrefType "journal-article" @default.
• W2042536320 hasAuthorship W2042536320A5050955692 @default.
• W2042536320 hasAuthorship W2042536320A5056942358 @default.
• W2042536320 hasAuthorship W2042536320A5077044814 @default.
• W2042536320 hasConcept C101544691 @default.
• W2042536320 hasConcept C112446052 @default.
• W2042536320 hasConcept C11960822 @default.
• W2042536320 hasConcept C126322002 @default.
• W2042536320 hasConcept C134018914 @default.
• W2042536320 hasConcept C150109051 @default.
• W2042536320 hasConcept C170493617 @default.
• W2042536320 hasConcept C185592680 @default.
• W2042536320 hasConcept C185967709 @default.
• W2042536320 hasConcept C197902417 @default.
• W2042536320 hasConcept C2776165026 @default.
• W2042536320 hasConcept C2777391703 @default.
• W2042536320 hasConcept C2777553839 @default.
• W2042536320 hasConcept C2779306644 @default.
• W2042536320 hasConcept C42362537 @default.

• next