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• W2042542014 abstract "Five components of behavior elicited by dopamine (DA) agonists (locomotor hyperactivity, sniffing, oral activity, grooming and paw nibbling) were evaluated after bilateral infusion of the selective D1 agonist fenoldopam (SKF 82526; 2.5–10 μg), the selective D2 agonist quinpirole (LY 171555; 5–40 μg) and the muscarinic antagonist scopolamine (5–10 μg) into the ventral striatum of awake, unrestrained rats. Simultaneous bilateral infusion of various dose combinations of fenoldopam (2.5–10 μm) and quinpirole (5–20 μg) elicited dramatic increases in stereotyped behaviors relative to the effects produced by corresponding doses of each drug alone. Stereotyped sniffing and paw nibbling (self-directed oral activity) were markedly enhanced, whereas conventional oral behaviors (licking, chewing and/or biting) were either slightly or not at all increased. These potentiated responses were reduced or blocked by concomitant infusion of either the selective D1 antagonist SCH 23390 (1 and 5 μg) or the selective D2 antagonist sulpiride (0.15 μg). Scopolamine (10 μg) only slightly increased the effects of quinpirole (5 mug) on both sniffing and oral behaviors, whereas it dramatically potentiated the effects of fenoldopam (2.5 mug) on oral activity; sniffing was only slightly increased. The effects of both drug combinations were almost completely antagonized by infusion of either SCH 23390 (1 μg) or sulpiride (0.1 μg). The results demonstrate that the synergistic effects of co-activation of D1 and D2 receptors observed after systematic administration are mediated at least in part by an interaction at the level of striatum. Differences and similarities between the behaviors expressed after various treatments are discussed." @default.
• W2042542014 created "2016-06-24" @default.
• W2042542014 creator A5050180649 @default.
• W2042542014 creator A5079755833 @default.
• W2042542014 date "1989-12-01" @default.
• W2042542014 modified "2023-10-03" @default.
• W2042542014 title "Enhanced behavioral stereotypies elicited by intrastriatal injection of D1 and D2 dopamine agonists in intact rats" @default.
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• W2042542014 doi "https://doi.org/10.1016/0006-8993(89)91368-1" @default.
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