FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042546551> ?p ?o ?g. }

• W2042546551 endingPage "583" @default.
• W2042546551 startingPage "577" @default.
• W2042546551 abstract "CD8 T-cell responses constitute a key host defense mechanism against tumor cells and a variety of viral infections, including retroviral infections that lead to acquired immunodeficiency. However, both for tumor cells and for many viral infections, there can be a relative paucity of immunodominant protective CD8 T-cell responses. For retroviruses, their rapid and error-prone replication, coupled with initial CD8 T-cell immunoselection of epitope-variant, retroviral quasi-species, are major impediments to sustaining a protective CD8 T-cell response. To approach this limitation of functional CD8 T-cell epitopes, here we further characterize an underappreciated source of additional T-cell epitopes: cryptic determinants, in particular those encoded in unconventional, alternative reading frames (ARFs). By use of the CD8 T-cell epitope, SYNTGRFPPL, which we have defined as encoded by the +1NT ARF of the gag gene of the LP-BM5 retrovirus that causes murine AIDS, we further characterize the regulation of ARF-epitope expression. Specifically, we examine the translation initiation requirements for production of sufficient epitope for effector CD8 T-cell recognition. Such translation must arise from rare frame-shifting events, making it crucial to understand any other constraints on epitope production, and therefore on the ability of the anti-Kd/SYNTGRFPPL CD8 T cells to protect from LP-BM5 pathogenesis and retroviral load, as we have previously shown. The data herein demonstrate that ARF epitope production depends entirely on conventional AUG-initiated translation, and that the more proximal in-frame ARF AUG is most important. However, maximal epitope production for protective CD8 T-cell lytic function also requires synergy of this initiation codon with a counterpart conventional AUG codon upstream in the same ARF (ORF 2), and with the classic ORF 1 AUG that initiates conventional gag polyprotein translation. These results have implications for the design of ARF-epitope-based vaccines, both to counter retroviral pathogenesis, as well as potentially more broadly, including in tumor systems." @default.
• W2042546551 created "2016-06-24" @default.
• W2042546551 creator A5049644755 @default.
• W2042546551 creator A5071281003 @default.
• W2042546551 creator A5072296070 @default.
• W2042546551 date "2010-12-01" @default.
• W2042546551 modified "2023-09-25" @default.
• W2042546551 title "Alternative Translational Reading Frames as a Novel Source of Epitopes for an Expanded CD8 T-Cell Repertoire: Use of a Retroviral System to Assess the Translational Requirements for CTL Recognition and Lysis" @default.
• W2042546551 cites W1483301458 @default.
• W2042546551 cites W1498992791 @default.
• W2042546551 cites W1506927838 @default.
• W2042546551 cites W1522694436 @default.
• W2042546551 cites W1563013015 @default.
• W2042546551 cites W1673344236 @default.
• W2042546551 cites W1897890183 @default.
• W2042546551 cites W1925735392 @default.
• W2042546551 cites W1964096433 @default.
• W2042546551 cites W1969901909 @default.
• W2042546551 cites W1971140237 @default.
• W2042546551 cites W1976953933 @default.
• W2042546551 cites W1977409285 @default.
• W2042546551 cites W1978480556 @default.
• W2042546551 cites W2014946585 @default.
• W2042546551 cites W2014963034 @default.
• W2042546551 cites W2021676181 @default.
• W2042546551 cites W2030335403 @default.
• W2042546551 cites W2034651502 @default.
• W2042546551 cites W2052196168 @default.
• W2042546551 cites W2057386135 @default.
• W2042546551 cites W2059289017 @default.
• W2042546551 cites W2069874313 @default.
• W2042546551 cites W2078542651 @default.
• W2042546551 cites W2084323507 @default.
• W2042546551 cites W2088849552 @default.
• W2042546551 cites W2097877316 @default.
• W2042546551 cites W2112327668 @default.
• W2042546551 cites W2134416175 @default.
• W2042546551 cites W2141295355 @default.
• W2042546551 cites W2144550666 @default.
• W2042546551 cites W2160185176 @default.
• W2042546551 cites W2166124085 @default.
• W2042546551 cites W2325916690 @default.
• W2042546551 doi "https://doi.org/10.1089/vim.2010.0057" @default.
• W2042546551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2991181" @default.
• W2042546551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21142443" @default.
• W2042546551 hasPublicationYear "2010" @default.
• W2042546551 type Work @default.
• W2042546551 sameAs 2042546551 @default.
• W2042546551 citedByCount "8" @default.
• W2042546551 countsByYear W20425465512012 @default.
• W2042546551 countsByYear W20425465512013 @default.
• W2042546551 countsByYear W20425465512015 @default.
• W2042546551 countsByYear W20425465512020 @default.
• W2042546551 crossrefType "journal-article" @default.
• W2042546551 hasAuthorship W2042546551A5049644755 @default.
• W2042546551 hasAuthorship W2042546551A5071281003 @default.
• W2042546551 hasAuthorship W2042546551A5072296070 @default.
• W2042546551 hasBestOaLocation W20425465512 @default.
• W2042546551 hasConcept C147483822 @default.
• W2042546551 hasConcept C147969180 @default.
• W2042546551 hasConcept C154317977 @default.
• W2042546551 hasConcept C159047783 @default.
• W2042546551 hasConcept C167672396 @default.
• W2042546551 hasConcept C195616568 @default.
• W2042546551 hasConcept C202751555 @default.
• W2042546551 hasConcept C2522874641 @default.
• W2042546551 hasConcept C2776090121 @default.
• W2042546551 hasConcept C2778431562 @default.
• W2042546551 hasConcept C54355233 @default.
• W2042546551 hasConcept C86803240 @default.
• W2042546551 hasConcept C8891405 @default.
• W2042546551 hasConcept C95444343 @default.
• W2042546551 hasConceptScore W2042546551C147483822 @default.
• W2042546551 hasConceptScore W2042546551C147969180 @default.
• W2042546551 hasConceptScore W2042546551C154317977 @default.
• W2042546551 hasConceptScore W2042546551C159047783 @default.
• W2042546551 hasConceptScore W2042546551C167672396 @default.
• W2042546551 hasConceptScore W2042546551C195616568 @default.
• W2042546551 hasConceptScore W2042546551C202751555 @default.
• W2042546551 hasConceptScore W2042546551C2522874641 @default.
• W2042546551 hasConceptScore W2042546551C2776090121 @default.
• W2042546551 hasConceptScore W2042546551C2778431562 @default.
• W2042546551 hasConceptScore W2042546551C54355233 @default.
• W2042546551 hasConceptScore W2042546551C86803240 @default.
• W2042546551 hasConceptScore W2042546551C8891405 @default.
• W2042546551 hasConceptScore W2042546551C95444343 @default.
• W2042546551 hasIssue "6" @default.
• W2042546551 hasLocation W20425465511 @default.
• W2042546551 hasLocation W20425465512 @default.
• W2042546551 hasLocation W20425465513 @default.
• W2042546551 hasLocation W20425465514 @default.
• W2042546551 hasOpenAccess W2042546551 @default.
• W2042546551 hasPrimaryLocation W20425465511 @default.
• W2042546551 hasRelatedWork W1513178816 @default.
• W2042546551 hasRelatedWork W2040554954 @default.
• W2042546551 hasRelatedWork W2052483994 @default.
• W2042546551 hasRelatedWork W2087643987 @default.
• W2042546551 hasRelatedWork W2119517715 @default.

• next