FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042562430> ?p ?o ?g. }

• W2042562430 endingPage "752" @default.
• W2042562430 startingPage "746" @default.
• W2042562430 abstract "Using a recently developed model for studying the biology of locally recurrent (LR) mammary tumours in the 13762NF rat mammary adenocarcinoma system, we examined the sensitivity to polymorphonuclear cell, macrophage and natural killer cell cytolysis. The parental MTF7(T20) cell line; the 'primary' tumours which arose following subcutaneous inoculation into the mammary fat pad, sc1 and sc3; and the local recurrences (following surgical excision) LR1 and LR1a from sc1, and LR3 from sc3 were all cells generally resistant to specific PMN cytolysis. LPS-activated macrophages caused 25.1%, 38.7% and 58.8% specific cytolysis in MTF7, sc1 and LR1 cells, respectively at E:T of 20:1 and 72 h co-incubation. LR1a, sc3 and LR3 lysis ranged from 0-4.4% under the same conditions. Non-activated macrophages did not lyse any of the cell lines. Locally recurrent and 'primary' tumour cell lines were also not lysed by naive NK cells (range 0.5-4.0% cytolysis). NK cells activated with bropirimine, a potent immunomodulator currently being studied in clinical trials, and/or interleukin-2 were mildly more effective at killing LR cells. Our results show that locally recurrent tumours exhibit heterogeneous sensitivities and are different from 'primary' tumour cells in sensitivities to immune cell killing, but they are not necessarily more or less sensitive. Results with bropirimine-activated or IL-2-activated NK cells emphasize that nonspecific activation is insufficient to eliminate all tumour subpopulations." @default.
• W2042562430 created "2016-06-24" @default.
• W2042562430 creator A5056217370 @default.
• W2042562430 creator A5063413818 @default.
• W2042562430 date "1988-12-01" @default.
• W2042562430 modified "2023-10-06" @default.
• W2042562430 title "Sensitivity of locally recurrent rat mammary tumour cell lines to syngeneic polymorphonuclear cell, macrophage and natural killer cell cytolysis" @default.
• W2042562430 cites W11894291 @default.
• W2042562430 cites W1520540177 @default.
• W2042562430 cites W1534154068 @default.
• W2042562430 cites W1557784459 @default.
• W2042562430 cites W1567417500 @default.
• W2042562430 cites W1575420123 @default.
• W2042562430 cites W1581118634 @default.
• W2042562430 cites W1762474897 @default.
• W2042562430 cites W1851967180 @default.
• W2042562430 cites W1869601273 @default.
• W2042562430 cites W1876684013 @default.
• W2042562430 cites W1921965923 @default.
• W2042562430 cites W1960278053 @default.
• W2042562430 cites W1978981580 @default.
• W2042562430 cites W1980196068 @default.
• W2042562430 cites W1984074329 @default.
• W2042562430 cites W1986531619 @default.
• W2042562430 cites W1995589202 @default.
• W2042562430 cites W2000685912 @default.
• W2042562430 cites W2016040499 @default.
• W2042562430 cites W2022913686 @default.
• W2042562430 cites W2034030378 @default.
• W2042562430 cites W2054780576 @default.
• W2042562430 cites W2055499537 @default.
• W2042562430 cites W2059169426 @default.
• W2042562430 cites W2062473801 @default.
• W2042562430 cites W2068489175 @default.
• W2042562430 cites W2073715427 @default.
• W2042562430 cites W2079367324 @default.
• W2042562430 cites W2079396969 @default.
• W2042562430 cites W2094340959 @default.
• W2042562430 cites W2117668915 @default.
• W2042562430 cites W2142853478 @default.
• W2042562430 cites W4298032220 @default.
• W2042562430 cites W2411581675 @default.
• W2042562430 doi "https://doi.org/10.1038/bjc.1988.302" @default.
• W2042562430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2246853" @default.
• W2042562430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3224080" @default.
• W2042562430 hasPublicationYear "1988" @default.
• W2042562430 type Work @default.
• W2042562430 sameAs 2042562430 @default.
• W2042562430 citedByCount "3" @default.
• W2042562430 countsByYear W20425624302012 @default.
• W2042562430 countsByYear W20425624302015 @default.
• W2042562430 countsByYear W20425624302020 @default.
• W2042562430 crossrefType "journal-article" @default.
• W2042562430 hasAuthorship W2042562430A5056217370 @default.
• W2042562430 hasAuthorship W2042562430A5063413818 @default.
• W2042562430 hasBestOaLocation W20425624302 @default.
• W2042562430 hasConcept C109316439 @default.
• W2042562430 hasConcept C1491633281 @default.
• W2042562430 hasConcept C202751555 @default.
• W2042562430 hasConcept C203014093 @default.
• W2042562430 hasConcept C2777701055 @default.
• W2042562430 hasConcept C2778102761 @default.
• W2042562430 hasConcept C2779244956 @default.
• W2042562430 hasConcept C502942594 @default.
• W2042562430 hasConcept C54355233 @default.
• W2042562430 hasConcept C55493867 @default.
• W2042562430 hasConcept C57409179 @default.
• W2042562430 hasConcept C73588182 @default.
• W2042562430 hasConcept C81885089 @default.
• W2042562430 hasConcept C86803240 @default.
• W2042562430 hasConcept C8891405 @default.
• W2042562430 hasConceptScore W2042562430C109316439 @default.
• W2042562430 hasConceptScore W2042562430C1491633281 @default.
• W2042562430 hasConceptScore W2042562430C202751555 @default.
• W2042562430 hasConceptScore W2042562430C203014093 @default.
• W2042562430 hasConceptScore W2042562430C2777701055 @default.
• W2042562430 hasConceptScore W2042562430C2778102761 @default.
• W2042562430 hasConceptScore W2042562430C2779244956 @default.
• W2042562430 hasConceptScore W2042562430C502942594 @default.
• W2042562430 hasConceptScore W2042562430C54355233 @default.
• W2042562430 hasConceptScore W2042562430C55493867 @default.
• W2042562430 hasConceptScore W2042562430C57409179 @default.
• W2042562430 hasConceptScore W2042562430C73588182 @default.
• W2042562430 hasConceptScore W2042562430C81885089 @default.
• W2042562430 hasConceptScore W2042562430C86803240 @default.
• W2042562430 hasConceptScore W2042562430C8891405 @default.
• W2042562430 hasIssue "6" @default.
• W2042562430 hasLocation W20425624301 @default.
• W2042562430 hasLocation W20425624302 @default.
• W2042562430 hasLocation W20425624303 @default.
• W2042562430 hasLocation W20425624304 @default.
• W2042562430 hasOpenAccess W2042562430 @default.
• W2042562430 hasPrimaryLocation W20425624301 @default.
• W2042562430 hasRelatedWork W1569612072 @default.
• W2042562430 hasRelatedWork W1578197313 @default.
• W2042562430 hasRelatedWork W1970400354 @default.
• W2042562430 hasRelatedWork W1987217913 @default.
• W2042562430 hasRelatedWork W2033686811 @default.

• next