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• W2042563500 abstract "A new controller of anON/OFF type was implemented for halothane anesthesia. A proportional-plus-integral controller with time-delay compensation proved not to be robust enough for the known clinical situation, as shown both in computer simulations and in animal trials. TheON/OFF controller proved to be less sensitive to parameter mismatches, and repeated animal trials showed a short response time and acceptable steady-state tracking. A method for switching the controlled effect of the drug was also developed, since anesthetic agents have multiple effects. Mean arterial blood pressure and a measure ofEEG frequency were chosen as controlled variables, both being depressed by halothane. A coordinator forces the system state as near the desired values of these variables as possible, given that only one drug is used." @default.
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• W2042563500 date "1987-01-01" @default.
• W2042563500 modified "2023-09-25" @default.
• W2042563500 title "Automatic control of anesthesia using two feedback variables" @default.
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• W2042563500 doi "https://doi.org/10.1007/bf02364165" @default.
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