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• W2042568900 abstract "Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. Higher concentrations of isocitrate, but not taurocholate, are also associated with worse cardiovascular health at baseline, as well as risk of future cardiovascular disease and death. None of the metabolites identified are associated with cancer risk. Our findings suggest that some, but not all, metabolic pathways related to human longevity are linked to the risk of common causes of death. Metabolomic profiling provides clues at alterations in cellular biochemistry. Here, the authors perform metabolomics analyses on samples from the Framingham Heart Study, and a Danish validation cohort, to identify small-molecule biomarkers prospectively associated with longevity or ageing." @default.
• W2042568900 created "2016-06-24" @default.
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• W2042568900 date "2015-04-13" @default.
• W2042568900 modified "2023-10-17" @default.
• W2042568900 title "Distinct metabolomic signatures are associated with longevity in humans" @default.
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• W2042568900 doi "https://doi.org/10.1038/ncomms7791" @default.
• W2042568900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4396657" @default.
• W2042568900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25864806" @default.
• W2042568900 hasPublicationYear "2015" @default.
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