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• W2042578855 abstract "Serotonin and its various receptors are involved in numerous brain functions and neuropsychiatric disorders. The 5-HT1A family is the best characterized subtype of the fourteen currently known 5-HT receptors. The 5-HT1A receptor is closely involved in the pathogenesis of anxiety, depression, epilepsy and eating disorders and therefore is an important target for drug therapy. The development in the 1980s of molecules specifically targeting this receptor was followed by the rapid development of corresponding PET neuroimaging. Because this receptor represents a crucial target in neuroscience, a large number of radioligands have been developed by academic and industry centers for visualization and quantification, first in living animals and ultimately in humans. After a brief account of some of the structural and functional characteristics of brain 5-HT1A receptors, this review focuses on the main lines of evolutionopened up by preclinical and clinical 5-HT1A PET radiopharmaceuticals, illustrating the potential value of PET for clinical research and drug development. Keywords: Agonist, antagonist, neurotransmission, positron emission tomography, radiopharmaceutical, 5-HT1A receptor." @default.
• W2042578855 created "2016-06-24" @default.
• W2042578855 creator A5020834018 @default.
• W2042578855 creator A5028037477 @default.
• W2042578855 creator A5029428115 @default.
• W2042578855 date "2013-11-01" @default.
• W2042578855 modified "2023-10-13" @default.
• W2042578855 title "PET Radiotracers for Molecular Imaging of Serotonin 5-HT_1A Receptors" @default.
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