FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042581201> ?p ?o ?g. }

• W2042581201 endingPage "391" @default.
• W2042581201 startingPage "384" @default.
• W2042581201 abstract "Summary B cells and dendritic cells, lacking functional Wiskott–Aldrich syndrome protein (WASP), have aberrant formation of membrane protrusions. We hypothesized that protrusions may play a role in antigen presentation, and consequently, that impaired antigen presentation may be an underlying factor of the immune deficiency in patients with Wiskott–Aldrich syndrome. In this paper, we investigated the antigen presentation capacity of B cells and dendritic cells from WASP knockout mice, using soluble and particulate antigen, to CD4 + T cells from T‐cell receptor transgenic DO11.10 mice. As antigen we used soluble ovalbumin (OVA), a peptide thereof (amino acids 323–339) or bacteria expressing OVA. We found that WASP‐deficient B cells and dendritic cells efficiently processed and presented soluble OVA protein as well as its peptide in vitro , inducing proliferation and cytokine production from CD4 + T cells. Antigen presentation of soluble protein was efficient also in vivo , because immunization of WASP‐deficient mice with OVA elicited proliferation of transferred, fluorescent‐labelled, CD4 + T cells. Although we could detect uptake of bacteria in dendritic cells, processing and presentation of bacterial‐expressed OVA was impaired in WASP‐deficient dendritic cells. In conclusion, our data suggest that WASP is not needed for processing and presentation of soluble antigen, but that efficient presentation of particulate antigen require WASP." @default.
• W2042581201 created "2016-06-24" @default.
• W2042581201 creator A5021668649 @default.
• W2042581201 creator A5037357405 @default.
• W2042581201 creator A5086532237 @default.
• W2042581201 creator A5087698737 @default.
• W2042581201 creator A5091546357 @default.
• W2042581201 date "2003-06-16" @default.
• W2042581201 modified "2023-10-16" @default.
• W2042581201 title "Efficient antigen presentation of soluble, but not particulate, antigen in the absence of Wiskott-Aldrich syndrome protein" @default.
• W2042581201 cites W1497033324 @default.
• W2042581201 cites W1508883873 @default.
• W2042581201 cites W1516680782 @default.
• W2042581201 cites W1524321385 @default.
• W2042581201 cites W1532545761 @default.
• W2042581201 cites W1538520630 @default.
• W2042581201 cites W1550538257 @default.
• W2042581201 cites W1575892864 @default.
• W2042581201 cites W1975784948 @default.
• W2042581201 cites W1977513008 @default.
• W2042581201 cites W1992949591 @default.
• W2042581201 cites W1997257161 @default.
• W2042581201 cites W2002497151 @default.
• W2042581201 cites W2003418627 @default.
• W2042581201 cites W2014304617 @default.
• W2042581201 cites W2015847022 @default.
• W2042581201 cites W2016253390 @default.
• W2042581201 cites W2029767028 @default.
• W2042581201 cites W2031123547 @default.
• W2042581201 cites W2043646282 @default.
• W2042581201 cites W2043763151 @default.
• W2042581201 cites W2045008512 @default.
• W2042581201 cites W2046167093 @default.
• W2042581201 cites W2049811440 @default.
• W2042581201 cites W2066013154 @default.
• W2042581201 cites W2066320353 @default.
• W2042581201 cites W2068669952 @default.
• W2042581201 cites W2072141011 @default.
• W2042581201 cites W2078384542 @default.
• W2042581201 cites W2086974999 @default.
• W2042581201 cites W2104327761 @default.
• W2042581201 cites W2111220263 @default.
• W2042581201 cites W2111528051 @default.
• W2042581201 cites W2112600997 @default.
• W2042581201 cites W2144120552 @default.
• W2042581201 cites W2159952680 @default.
• W2042581201 cites W2163351493 @default.
• W2042581201 cites W2165364837 @default.
• W2042581201 cites W2168537923 @default.
• W2042581201 cites W2170515238 @default.
• W2042581201 cites W2262065180 @default.
• W2042581201 cites W2409904394 @default.
• W2042581201 cites W2419617303 @default.
• W2042581201 cites W4252692871 @default.
• W2042581201 cites W4313333817 @default.
• W2042581201 doi "https://doi.org/10.1046/j.1365-2567.2003.01668.x" @default.
• W2042581201 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1782978" @default.
• W2042581201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12807484" @default.
• W2042581201 hasPublicationYear "2003" @default.
• W2042581201 type Work @default.
• W2042581201 sameAs 2042581201 @default.
• W2042581201 citedByCount "38" @default.
• W2042581201 countsByYear W20425812012012 @default.
• W2042581201 countsByYear W20425812012013 @default.
• W2042581201 countsByYear W20425812012015 @default.
• W2042581201 countsByYear W20425812012016 @default.
• W2042581201 countsByYear W20425812012017 @default.
• W2042581201 countsByYear W20425812012019 @default.
• W2042581201 countsByYear W20425812012020 @default.
• W2042581201 countsByYear W20425812012023 @default.
• W2042581201 crossrefType "journal-article" @default.
• W2042581201 hasAuthorship W2042581201A5021668649 @default.
• W2042581201 hasAuthorship W2042581201A5037357405 @default.
• W2042581201 hasAuthorship W2042581201A5086532237 @default.
• W2042581201 hasAuthorship W2042581201A5087698737 @default.
• W2042581201 hasAuthorship W2042581201A5091546357 @default.
• W2042581201 hasBestOaLocation W20425812011 @default.
• W2042581201 hasConcept C108249834 @default.
• W2042581201 hasConcept C142669718 @default.
• W2042581201 hasConcept C147483822 @default.
• W2042581201 hasConcept C1491633281 @default.
• W2042581201 hasConcept C154317977 @default.
• W2042581201 hasConcept C202751555 @default.
• W2042581201 hasConcept C203014093 @default.
• W2042581201 hasConcept C2776090121 @default.
• W2042581201 hasConcept C2776946954 @default.
• W2042581201 hasConcept C2778170410 @default.
• W2042581201 hasConcept C2780939953 @default.
• W2042581201 hasConcept C2993400109 @default.
• W2042581201 hasConcept C39347974 @default.
• W2042581201 hasConcept C55493867 @default.
• W2042581201 hasConcept C67662055 @default.
• W2042581201 hasConcept C83464605 @default.
• W2042581201 hasConcept C86803240 @default.
• W2042581201 hasConcept C8891405 @default.
• W2042581201 hasConcept C95444343 @default.
• W2042581201 hasConceptScore W2042581201C108249834 @default.
• W2042581201 hasConceptScore W2042581201C142669718 @default.

• next