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- W2042582008 abstract "Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. Its cardinal clinical features are bradykinesia, rigidity, tremor, and postural instability. Although the early dominant motor features of PD are related to dopaminergic cell death in the substantia nigra, there are additional foci of neurodegeneration which also begin at an early stage and progress. Involvement of the non-dopaminergic systems results in a variety of clinical features that are refractory to current symptomatic therapy. These include cognitive disturbance, depression, gait disturbance, and autonomic abnormalities. Sleep disorders can now be added to this list. The disturbance of sleep and daytime wakefulness in PD patients is now recognized to be extremely common. Sleep disorders have a complex etiology related not only to the underlying neurodegenerative process but also to the motor and non-motor features of PD and to dopaminergic therapy. This review addresses the issue of excessive daytime somnolence and its relationship to other sleep disturbances in PD.A number of studies have sought to estimate the frequency of sleep disorders in patients with PD. The results have varied widely, reflecting the influence of different variables such as the definition of sleep disturbance, the method of ascertainment, and the population under study, i.e., community versus hospital-based.1–9⇓⇓⇓⇓⇓⇓⇓⇓ In general, these early studies have indicated that more than half and as many as 80 to 90% of PD patients have some disturbance of sleep patterns. Two community-based studies addressed this problem. The first was based in Norway, and 239 PD patients were interviewed and examined.5 These patients were compared with 100 normal age-matched controls and 100 patients with diabetes mellitus. The questionnaire focused on patient experience during the night and inquired about specific details relating to, e.g., sleep initiation, awakenings, and early …" @default.
- W2042582008 created "2016-06-24" @default.
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- W2042582008 date "2004-10-25" @default.
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- W2042582008 title "Excessive daytime sleepiness in Parkinson's disease" @default.
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- W2042582008 doi "https://doi.org/10.1212/wnl.63.8_suppl_3.s24" @default.
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