Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042582017> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2042582017 endingPage "933" @default.
- W2042582017 startingPage "925" @default.
- W2042582017 abstract "ACTH1–24, its o-nitrophenyl sulfenyl derivative and ACTH11–24 were iodinated by the chloramine T method and purified on carboxymethylcellulose. Enzymatic digestion shows that all the iodine was incorporated in the form of monoiodotyrosine. The three ACTHs bound to adrenal crude membranes (pellet 20,000 g) prepared from normal human, rat and sheep adrenals. In the presence of an excess of membrane protein more than 60% of the radioactivity was bound specifically. The binding of 125I-ACTH1–24 to its adrenal receptor is very rapid; it is temperature dependent, inhibited by ions and by the pancreatic trypsin inhibitor. ACTH1–24 and its o-nitrophenyl sulfenyl derivative inhibited identically the binding of 125I-ACTH1–24. ACTH11–24 and ACTH1–10 were only, respectively, 15% and 6%, as active as ACTH1–24 in displacing the bound 125I-ACTH1–24. The binding of 125I-ACTH11–24 is more inhibited by ACTH1–24 than by ACTH11–24 ACTH1–10 at high concentrations (10−4 M) had no effect. The adenyl cyclase of the same adrenal preparations was stimulated by ACTH1–24; NPS-ACTH1–24 stimulated adenyl cyclase activity but inhibited the action induced by ACTH1–24 in the same way as ACTH11–24 which was without effect on adenyl cyclase. On the other hand, ACTH1–10 stimulated adenyl cyclase activity and its action was additional to ACTH1–24. It can be concluded that the 1–10 N-terminal sequence of ACTH, in addition to being the biological active site of the molecule, contributes to binding and increases the affinity of ACTH for its receptor." @default.
- W2042582017 created "2016-06-24" @default.
- W2042582017 creator A5002021348 @default.
- W2042582017 creator A5045044977 @default.
- W2042582017 creator A5059210887 @default.
- W2042582017 creator A5082177855 @default.
- W2042582017 date "1974-12-01" @default.
- W2042582017 modified "2023-10-18" @default.
- W2042582017 title "Interactions of acth with its adrenal receptors: Specific binding of ACTH1–24, its O-nitrophenyl sulfenyl derivative and ACTH11–24" @default.
- W2042582017 cites W1505515713 @default.
- W2042582017 cites W1530431885 @default.
- W2042582017 cites W1540704693 @default.
- W2042582017 cites W1589700202 @default.
- W2042582017 cites W1657719861 @default.
- W2042582017 cites W1956627733 @default.
- W2042582017 cites W1968545882 @default.
- W2042582017 cites W1987399998 @default.
- W2042582017 cites W1989859410 @default.
- W2042582017 cites W1999003113 @default.
- W2042582017 cites W2002911874 @default.
- W2042582017 cites W2012701629 @default.
- W2042582017 cites W2017609319 @default.
- W2042582017 cites W2020802691 @default.
- W2042582017 cites W2032860381 @default.
- W2042582017 cites W2043475832 @default.
- W2042582017 cites W2046628065 @default.
- W2042582017 cites W2054279604 @default.
- W2042582017 cites W2075766984 @default.
- W2042582017 cites W2085214035 @default.
- W2042582017 cites W2088205083 @default.
- W2042582017 cites W2174414872 @default.
- W2042582017 cites W2417412181 @default.
- W2042582017 cites W4238110810 @default.
- W2042582017 doi "https://doi.org/10.1016/0022-4731(74)90087-9" @default.
- W2042582017 hasPublicationYear "1974" @default.
- W2042582017 type Work @default.
- W2042582017 sameAs 2042582017 @default.
- W2042582017 citedByCount "27" @default.
- W2042582017 crossrefType "journal-article" @default.
- W2042582017 hasAuthorship W2042582017A5002021348 @default.
- W2042582017 hasAuthorship W2042582017A5045044977 @default.
- W2042582017 hasAuthorship W2042582017A5059210887 @default.
- W2042582017 hasAuthorship W2042582017A5082177855 @default.
- W2042582017 hasConcept C107824862 @default.
- W2042582017 hasConcept C170493617 @default.
- W2042582017 hasConcept C181199279 @default.
- W2042582017 hasConcept C185592680 @default.
- W2042582017 hasConcept C2777977426 @default.
- W2042582017 hasConcept C2780069284 @default.
- W2042582017 hasConcept C2780340462 @default.
- W2042582017 hasConcept C55493867 @default.
- W2042582017 hasConceptScore W2042582017C107824862 @default.
- W2042582017 hasConceptScore W2042582017C170493617 @default.
- W2042582017 hasConceptScore W2042582017C181199279 @default.
- W2042582017 hasConceptScore W2042582017C185592680 @default.
- W2042582017 hasConceptScore W2042582017C2777977426 @default.
- W2042582017 hasConceptScore W2042582017C2780069284 @default.
- W2042582017 hasConceptScore W2042582017C2780340462 @default.
- W2042582017 hasConceptScore W2042582017C55493867 @default.
- W2042582017 hasIssue "8" @default.
- W2042582017 hasLocation W20425820171 @default.
- W2042582017 hasOpenAccess W2042582017 @default.
- W2042582017 hasPrimaryLocation W20425820171 @default.
- W2042582017 hasRelatedWork W161724055 @default.
- W2042582017 hasRelatedWork W1968105607 @default.
- W2042582017 hasRelatedWork W1970240495 @default.
- W2042582017 hasRelatedWork W1988153393 @default.
- W2042582017 hasRelatedWork W2015458932 @default.
- W2042582017 hasRelatedWork W2028317575 @default.
- W2042582017 hasRelatedWork W2037785646 @default.
- W2042582017 hasRelatedWork W2040702226 @default.
- W2042582017 hasRelatedWork W2144642362 @default.
- W2042582017 hasRelatedWork W2330682302 @default.
- W2042582017 hasVolume "5" @default.
- W2042582017 isParatext "false" @default.
- W2042582017 isRetracted "false" @default.
- W2042582017 magId "2042582017" @default.
- W2042582017 workType "article" @default.