FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042585533> ?p ?o ?g. }

• W2042585533 endingPage "470" @default.
• W2042585533 startingPage "463" @default.
• W2042585533 abstract "Objective— Lysophosphatidic acids (LPA) have important roles in the field of vascular biology and are derived mainly from lysophosphatidylcholine via autotaxin. However, in our previous study, only the plasma LPA levels, and not the serum autotaxin levels, increased in patients with acute coronary syndrome (ACS). The aim of this study was to elucidate the pathway by which LPA is increased in patients with ACS. Approach and Results— We measured the plasma lysophospholipids species in 141 consecutive patients undergoing coronary angiography (ACS, n=38; stable angina pectoris, n=71; angiographically normal coronary arteries, n=32) using a liquid chromatography-tandem mass spectrometry analysis. Among the ACS subjects, notable increases in the 22:6 LPA, 18:2 LPA, and 20:4 LPA levels were observed. The in vitro experiments revealed that serum incubation mainly increased the 18:2 LPA level, whereas platelet activation increased the 20:4 LPA level. Minor lysophospholipids other than LPA were also elevated in ACS subjects and were well correlated with the corresponding LPA species, including 22:6 LPA. A multiple regression analysis also revealed that lysophosphatidylinositol, lysophosphatidylcholine, lysophosphatidylethanolamine, and lysophosphatidylglycerol were independent explanatory variables for several LPA species. Conclusions— Specific LPA species, especially long-chain unsaturated LPA, were elevated in ACS patients, along with the corresponding minor lysophospholipids. The elevation of these LPA species might be mainly caused by presently unidentified LPA-producing pathway(s). Minor lysophospholipids might be involved in the generation of LPA, especially 22:6 LPA, and in the pathogenesis of ACS." @default.
• W2042585533 created "2016-06-24" @default.
• W2042585533 creator A5004677091 @default.
• W2042585533 creator A5026162371 @default.
• W2042585533 creator A5026353064 @default.
• W2042585533 creator A5029321254 @default.
• W2042585533 creator A5032489820 @default.
• W2042585533 creator A5036177715 @default.
• W2042585533 creator A5039065380 @default.
• W2042585533 creator A5043895289 @default.
• W2042585533 creator A5053123676 @default.
• W2042585533 creator A5058793966 @default.
• W2042585533 creator A5060462446 @default.
• W2042585533 creator A5064921157 @default.
• W2042585533 creator A5076375061 @default.
• W2042585533 creator A5077332068 @default.
• W2042585533 creator A5089204761 @default.
• W2042585533 creator A5090940706 @default.
• W2042585533 date "2015-02-01" @default.
• W2042585533 modified "2023-10-03" @default.
• W2042585533 title "Possible Involvement of Minor Lysophospholipids in the Increase in Plasma Lysophosphatidic Acid in Acute Coronary Syndrome" @default.
• W2042585533 cites W124732761 @default.
• W2042585533 cites W1555808871 @default.
• W2042585533 cites W1969583407 @default.
• W2042585533 cites W1980605432 @default.
• W2042585533 cites W1984783217 @default.
• W2042585533 cites W1990875180 @default.
• W2042585533 cites W1993235326 @default.
• W2042585533 cites W1997941330 @default.
• W2042585533 cites W1998037751 @default.
• W2042585533 cites W2008303551 @default.
• W2042585533 cites W2009021880 @default.
• W2042585533 cites W2018511244 @default.
• W2042585533 cites W2021389931 @default.
• W2042585533 cites W2025785613 @default.
• W2042585533 cites W2036011686 @default.
• W2042585533 cites W2046695461 @default.
• W2042585533 cites W2047645266 @default.
• W2042585533 cites W2051206607 @default.
• W2042585533 cites W2063159737 @default.
• W2042585533 cites W2068106019 @default.
• W2042585533 cites W2071792310 @default.
• W2042585533 cites W2072369801 @default.
• W2042585533 cites W2084676297 @default.
• W2042585533 cites W2092205926 @default.
• W2042585533 cites W2096597075 @default.
• W2042585533 cites W2098944687 @default.
• W2042585533 cites W2105692661 @default.
• W2042585533 cites W2107992161 @default.
• W2042585533 cites W2118171236 @default.
• W2042585533 cites W2128585253 @default.
• W2042585533 cites W2129241376 @default.
• W2042585533 cites W2141583613 @default.
• W2042585533 cites W2150932858 @default.
• W2042585533 cites W2156708860 @default.
• W2042585533 cites W2160870763 @default.
• W2042585533 cites W2161184363 @default.
• W2042585533 cites W2170603858 @default.
• W2042585533 doi "https://doi.org/10.1161/atvbaha.114.304748" @default.
• W2042585533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25425621" @default.
• W2042585533 hasPublicationYear "2015" @default.
• W2042585533 type Work @default.
• W2042585533 sameAs 2042585533 @default.
• W2042585533 citedByCount "69" @default.
• W2042585533 countsByYear W20425855332015 @default.
• W2042585533 countsByYear W20425855332016 @default.
• W2042585533 countsByYear W20425855332017 @default.
• W2042585533 countsByYear W20425855332018 @default.
• W2042585533 countsByYear W20425855332019 @default.
• W2042585533 countsByYear W20425855332020 @default.
• W2042585533 countsByYear W20425855332021 @default.
• W2042585533 countsByYear W20425855332022 @default.
• W2042585533 countsByYear W20425855332023 @default.
• W2042585533 crossrefType "journal-article" @default.
• W2042585533 hasAuthorship W2042585533A5004677091 @default.
• W2042585533 hasAuthorship W2042585533A5026162371 @default.
• W2042585533 hasAuthorship W2042585533A5026353064 @default.
• W2042585533 hasAuthorship W2042585533A5029321254 @default.
• W2042585533 hasAuthorship W2042585533A5032489820 @default.
• W2042585533 hasAuthorship W2042585533A5036177715 @default.
• W2042585533 hasAuthorship W2042585533A5039065380 @default.
• W2042585533 hasAuthorship W2042585533A5043895289 @default.
• W2042585533 hasAuthorship W2042585533A5053123676 @default.
• W2042585533 hasAuthorship W2042585533A5058793966 @default.
• W2042585533 hasAuthorship W2042585533A5060462446 @default.
• W2042585533 hasAuthorship W2042585533A5064921157 @default.
• W2042585533 hasAuthorship W2042585533A5076375061 @default.
• W2042585533 hasAuthorship W2042585533A5077332068 @default.
• W2042585533 hasAuthorship W2042585533A5089204761 @default.
• W2042585533 hasAuthorship W2042585533A5090940706 @default.
• W2042585533 hasBestOaLocation W20425855331 @default.
• W2042585533 hasConcept C126322002 @default.
• W2042585533 hasConcept C134018914 @default.
• W2042585533 hasConcept C170493617 @default.
• W2042585533 hasConcept C185592680 @default.
• W2042585533 hasConcept C2776330855 @default.
• W2042585533 hasConcept C2776661833 @default.
• W2042585533 hasConcept C2777698277 @default.

• next